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Volumetric and dosimetric comparison of computerised radiotherapy treatment plan between using positron emission tomography/computed tomography (PET/CT) and CT images for target delineation in non-small cell lung cancer patients

Published online by Cambridge University Press:  18 April 2016

Sanphat Sangudsup
Affiliation:
Medical Physics Master Degree Program, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Tawika Kaewchur
Affiliation:
Department of Radiology, Division of Nuclear Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Waralee Teeyasoontranon
Affiliation:
Department of Radiology, Division of Nuclear Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Pitchayaponne Klunklin
Affiliation:
Division of Therapeutic Radiology and Oncology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Nisa Chawapun
Affiliation:
Division of Therapeutic Radiology and Oncology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Supoj Ua-apisitwong*
Affiliation:
Department of Radiology, Division of Nuclear Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
*
Correspondence to: Supoj Ua-apisitwong, Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine, Chiang Mai University, 239 Huay Kaew Road, Muang District, Chiang Mai, Thailand, 50200. Tel: +66 83 5668983. E-mail: [email protected]

Abstract

Purpose

To compare intensity-modulated radiation therapy (IMRT) treatment planning between using positron emission tomography/computed tomography (PET/CT) and CT for target volume delineation in patients with non-small cell lung cancer (NSCLC).

Methods

Nine NSCLC patients with PET/CT images were enrolled into this study. Gross tumour volumes (GTVs) were delineated by the PET visual assessment (PETvis), the automated PET (PETauto), standardised uptake value (SUV)>2·5 (PET2·5) and threshold 40% SUVmax (PET40), and CT-based method. For each patient, two IMRT treatment plans based on CT and PET/CT delineation were performed. The target coverage and the dose–volume parameters for organs at risk were analysed.

Results

The PETauto referred to PET40 when SUVmax<7 and PET2·5 when SUVmax≥7. The mean GTVs were 15·04, 15·7 and 15·14 cc for PETauto, PETvis and CT based, respectively. The GTV of PETauto was not different from PETvis (p=0·441) and CT based (p=0·594). Based on CT delineation in IMRT planning, only 34% of the cases had sufficient PET/CT planning target volumes coverage, whereas the organs at risk dose parameters were not statistically significant (p>0·05).

Conclusions

PET/CT enables more accurate assessment of tumour delineation for NSCLC, therefore improve target coverage in IMRT plan.

Type
Original Articles
Copyright
© Cambridge University Press 2016 

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