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Significance of serum vascular endothelial growth factor and cancer antigen 15.3 in patients with triple negative breast cancer

Published online by Cambridge University Press:  23 April 2013

Priyanka Chanana ,
Awadesh Kumar Pandey ,
Budhi Singh Yadav ,
Jasbinder Kaur ,
Seema Singla ,
Kislay Dimri ,
Romeeta Trehan  and
Pawan Krishan
Priyanka Chanana
Affiliation:
Department of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, India
Awadesh Kumar Pandey
Affiliation:
Department of Radiotherapy and Oncology, Government Medical College and Hospital, Chandigarh, India
Budhi Singh Yadav*
Affiliation:
Department of Radiation Oncology, Regional Cancer Centre, Post Graduate Institute of Medical Education & Research, Chandigarh, India
Jasbinder Kaur
Affiliation:
Department of Biochemistry, Government Medical College and Hospital, Chandigarh, India
Seema Singla
Affiliation:
Department of Biochemistry, Government Medical College and Hospital, Chandigarh, India
Kislay Dimri
Affiliation:
Department of Radiotherapy and Oncology, Government Medical College and Hospital, Chandigarh, India
Romeeta Trehan
Affiliation:
Department of Radiotherapy and Oncology, Government Medical College and Hospital, Chandigarh, India
Pawan Krishan
Affiliation:
Department of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, India
*
Correspondence to: Dr Budhi Singh Yadav, Department of Radiation Oncology, Regional Cancer Centre, Post Graduate Institute of Medical Education & Research, Sector–12, Chandigarh, India. Tel: +91 981 598 1176. E-mail: [email protected]
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Abstract

Background

A pilot study was undertaken to find significance of vascular endothelial growth factor (VEGF) and cancer antigen (CA 15.3) in breast cancer patients.

Materials and methods

Total 70 patients with breast cancer were divided into triple negative breast cancer (TNBC) and non-TNBC depending on oestrogen receptors, progesterone receptors or HER-2/neu receptors status. Serum CA 15.3 and VEGF levels were evaluated with enzyme-linked immunosorbent assay at the time of diagnosis and were correlated with age, tumour size and stage of the disease in both the groups. Spearman's test was used to find the correlation.

Results

VEGF levels were found to be >400 pg/ml in 27 patients, 19 (54·33%) of them were TNBC and only 8 (22·87%) non-TNBC. Mean values of the VEGF were, 784·34 pg/ml in TNBC and 334·60 pg/ml non-TNBC patients, respectively. CA 15.3 level was found to be higher in non-TNBC group (60·72 U/ml) than in TNBC group (45·24 U/ml). In all patients significant correlation was found between serum CA 15.3 level and tumour size and stage of the disease. In non-TNBC patients significant correlation was seen between CA 15.3 values and stage of the disease, but VEGF had no correlation with any of the disease parameters. In TNBC patients, there was no correlation between CA 15.3 level and any of the disease parameters but VEGF showed a significant correlation with both tumour size and stage of the disease.

Conclusion

Expression profile of VEGF was high in TNBC than non-TNBC patients. VEGF serves to be a better biomarker as compared with CA 15.3 in TNBC patients.

Keywords

breast cancerCA 15.3TNBCtumour markersVEGF
Type
Original Articles
Information
Journal of Radiotherapy in Practice , Volume 13 , Issue 1 , March 2014 , pp. 60 - 67
Copyright
Copyright © Cambridge University Press 2013 

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