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Radiotherapy for histiocytic sarcoma: a case report

Published online by Cambridge University Press:  09 January 2015

Daniel J. Bourgeois III ,
Allison Dixon  and
Anurag K. Singh
Daniel J. Bourgeois III
Affiliation:
Roswell Park Cancer Institute, Buffalo, NY, USA
Allison Dixon
Affiliation:
Roswell Park Cancer Institute, Buffalo, NY, USA
Anurag K. Singh*
Affiliation:
Roswell Park Cancer Institute, Buffalo, NY, USA
*
Correspondence to: Anurag K. Singh, MD, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, 14263 NY, USA. Tel: (716) 845 - 1180; E-mail: [email protected]
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Abstract

Background

Histiocystic sarcoma is a rare, but aggressive tumour that often involves extranodal sites. Histiocystic sarcoma is recognised by the World Health Organization as one of six subtypes of dendritic cell neoplasms. Diagnosis is difficult due to overlapping immunohistochemistry with other dendritic cell neoplasms. The optimal roles for chemotherapy, radiotherapy and surgery in the treatment of histiocytic sarcoma remain unknown.

Methods

We report a case of a patient with histiocytic sarcoma diagnosed after excisional biopsy and immunohistochemistry testing.

Results

The patient underwent external beam radiation therapy (EBRT). After 18 Gray (Gy), the 8 cm lesion had regressed to ~5 cm in diameter. The treatments were continued to a total dose of 45 Gy with the lesion regressing to less than a centimeter by the end of treatment. Local control was maintained but the patient died of acute myelogenous leukemia 5 months after her treatment.

Conclusions

This case suggests that histicytic sarcomas can be controlled locally with EBRT.

Keywords

dendritic cellhistiocytic sarcomalymphomaradiationS100 protein
Type
Case Study
Information
Journal of Radiotherapy in Practice , Volume 14 , Issue 2 , June 2015 , pp. 212 - 215
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Copyright
© Cambridge University Press 2015 

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