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Proton beam radiotherapy of locally advanced or recurrent conjunctival squamous cell carcinoma: experience of the CATANA Centre

Published online by Cambridge University Press:  09 November 2020

Roberto Milazzotto Open the ORCID record for Roberto Milazzotto [Opens in a new window] ,
Rocco Luca Emanuele Liardo ,
Giuseppe Privitera ,
Luigi Raffaele ,
Vincenzo Salamone ,
Floriana Arena ,
Stefano Pergolizzi ,
Giacomo Cuttone ,
Giuseppe A. P. Cirrone  and
Andrea Russo
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Roberto Milazzotto*
Affiliation:
Department of Radiology and Radiotherapy, AOU Policlinico-VE di Catania, Catania95123, Italy
Rocco Luca Emanuele Liardo
Affiliation:
Department of Radiology and Radiotherapy, AOU Policlinico-VE di Catania, Catania95123, Italy
Giuseppe Privitera
Affiliation:
Department of Radiology and Radiotherapy, AOU Policlinico-VE di Catania, Catania95123, Italy
Luigi Raffaele
Affiliation:
Department of Radiology and Radiotherapy, AOU Policlinico-VE di Catania, Catania95123, Italy
Vincenzo Salamone
Affiliation:
Department of Radiology and Radiotherapy, AOU Policlinico-VE di Catania, Catania95123, Italy
Floriana Arena
Affiliation:
Department of Radiotherapy, AOU Policlinico di Messina, Messina98125, Italy
Stefano Pergolizzi
Affiliation:
Department of Radiotherapy, AOU Policlinico di Messina, Messina98125, Italy Department of Scienze biomediche, odontoiatriche e delle immagini morfologiche e funzionali, University of Messina, Messina98125, Italy
Giacomo Cuttone
Affiliation:
National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, Catania95123, Italy
Giuseppe A. P. Cirrone
Affiliation:
National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, Catania95123, Italy
Andrea Russo
Affiliation:
Department of Ophthalmology, AOU Policlinico-VE di Catania, Catania95123, Italy
Teresio Avitabile
Affiliation:
Department of Ophthalmology, AOU Policlinico-VE di Catania, Catania95123, Italy
Pietro Valerio Foti
Affiliation:
Department of Radiology and Radiotherapy, AOU Policlinico-VE di Catania, Catania95123, Italy Department of Scienze Mediche, Chirurgiche e Tecnologie Avanzate “G.F. Ingrassia”, University of Catania, Catania95123, Italy
Stefano Palmucci
Affiliation:
Department of Radiology and Radiotherapy, AOU Policlinico-VE di Catania, Catania95123, Italy Department of Scienze Mediche, Chirurgiche e Tecnologie Avanzate “G.F. Ingrassia”, University of Catania, Catania95123, Italy
Antonio Basile
Affiliation:
Department of Radiology and Radiotherapy, AOU Policlinico-VE di Catania, Catania95123, Italy Department of Scienze Mediche, Chirurgiche e Tecnologie Avanzate “G.F. Ingrassia”, University of Catania, Catania95123, Italy
Corrado Spatola
Affiliation:
Department of Radiology and Radiotherapy, AOU Policlinico-VE di Catania, Catania95123, Italy Department of Scienze Mediche, Chirurgiche e Tecnologie Avanzate “G.F. Ingrassia”, University of Catania, Catania95123, Italy
*
Author for correspondence: Dr Roberto Milazzotto, AOU Policlinico-VE di Catania, Via Santa Sofia 78, Catania95123, Italy. Tel: 0039-3493837901. Fax: 0039-0953781315. E-mail: [email protected]
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Abstract

Aim:

Conjunctival squamous cell carcinoma (SCC) is a rare tumour of the ocular region and microscopic radical surgical is difficult. There are no single guidelines for therapeutic management and the role of radiation therapy is not clearly defined although conventionally photon or electron beams are used. Proton beam radiotherapy (PBRT) is a new option for a conservative approach and allows good sparing of the organs at risk.

Materials and methods:

After surgical resection, we collected 15 cases treated at our institution with PBRT. The dose delivered was between 48 and 60 Gy relative biological effectiveness (RBE), with fractions of 12–15 Gy RBE.

Results:

After an average period of 48 months, the patients achieved excellent disease control (overall survival and disease-free survival: 86·6%), with minimal acute and late toxicity.

Findings:

In this work, we present our experience on the use of PBRT technique in SCC treatment. A larger sample of patients is needed to draw conclusions about the impact of this treatment on disease recurrence and overall survival.

Keywords

conjunctival squamous cell carcinomaSCCproton beam radiotherapyocular superficial squamous neoplasiaOSSN
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 21 , Issue 1 , March 2022 , pp. 97 - 104
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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