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Neuroendocrine carcinoma of the uterine cervix: 15-year experience from a tertiary care centre in Southern India

Published online by Cambridge University Press:  27 February 2020

Sobin V. Jacob Open the ORCID record for Sobin V. Jacob [Opens in a new window] ,
Arvind Sathyamurthy Open the ORCID record for Arvind Sathyamurthy [Opens in a new window] ,
Jeba Karunya Ramireddy ,
Anitha Thomas Open the ORCID record for Anitha Thomas [Opens in a new window] ,
Kaalindi Singh Open the ORCID record for Kaalindi Singh [Opens in a new window]  and
Thomas Samuel Ram Open the ORCID record for Thomas Samuel Ram [Opens in a new window]
Sobin V. Jacob
Affiliation:
Department of Radiation Oncology, Ida B Scudder Cancer Centre, Christian Medical College, Vellore, India
Arvind Sathyamurthy*
Affiliation:
Department of Radiation Oncology, Ida B Scudder Cancer Centre, Christian Medical College, Vellore, India
Jeba Karunya Ramireddy
Affiliation:
Department of Radiation Oncology, Ida B Scudder Cancer Centre, Christian Medical College, Vellore, India
Anitha Thomas
Affiliation:
Department of Gynecologic Oncology, Christian Medical College, Vellore, India
Kaalindi Singh
Affiliation:
Department of Radiation Oncology, Ida B Scudder Cancer Centre, Christian Medical College, Vellore, India
Thomas Samuel Ram
Affiliation:
Department of Radiation Oncology, Ida B Scudder Cancer Centre, Christian Medical College, Vellore, India
*
Author for correspondence: Arvind Sathyamurthy, Department of Radiation Oncology, Ida B Scudder Cancer Centre, Christian Medical College, Vellore, India. Tel: +919901294136. Email: [email protected]
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Abstract

Aim:

To analyse the presentation, treatment strategies and outcomes of neuroendocrine carcinoma of cervix treated with multi-modality approach at our institute.

Materials and methods:

The data of patients diagnosed to have cervical cancer between October 2004 and November 2018 were retrieved, and 14 patients of neuroendocrine carcinoma cervix who received treatment in our institution were identified. The patients were analysed based on demographic characteristics, disease stage, pathological characteristics, treatment and follow-up. The median overall survival and disease-free survival were calculated.

Results:

Median follow-up period was 8 months (range 1–52 months). Six patients died within 4 months of completion of treatment due to disease progression. Median overall survival was 12 months and median disease-free interval was 5·5 months. Four of the patients who underwent combined modality treatment consisting of neoadjuvant chemotherapy, concurrent chemoradiation therapy and brachytherapy are still on regular follow-up and are disease-free.

Conclusion:

Neuroendocrine carcinoma of the cervix is a rare but aggressive histological subtype. Combined modality approach with judicious use of systemic chemotherapy along with surgery and radiation therapy is essential for optimal outcomes.

Keywords

chemoradiationmulti-modality approachneuroendocrine carcinoma cervixpatterns of care
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 20 , Issue 2 , June 2021 , pp. 164 - 167
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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