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In vivo dosimetry using radiochromic films (EBT-2) during intraoperative radiotherapy

Published online by Cambridge University Press:  06 June 2016

Zahra Rahimzade Yekta ,
Seied Rabi Mehdi Mahdavi ,
Hamid Reza Baghani ,
Mostafa Robatjazi ,
Ahmad Mostaar ,
Hamidreza Mirzaie ,
Dariush Sardari ,
Mohammad Esmaeil Akbari  and
Nahid Nafisi
Zahra Rahimzade Yekta
Affiliation:
Sciences and Research Branch of Tehran, Islamic Azad University, Tehran, Iran
Seied Rabi Mehdi Mahdavi*
Affiliation:
Department of Medical Physics, Iran University of Medical Sciences, Tehran, Iran
Hamid Reza Baghani
Affiliation:
Department of Radiation Medicine, Shahid Beheshti University, Tehran, Iran
Mostafa Robatjazi
Affiliation:
Department of Medical Physics, Tehran University of medical Science, Tehran, Iran
Ahmad Mostaar
Affiliation:
Department of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Hamidreza Mirzaie
Affiliation:
Department of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Dariush Sardari
Affiliation:
Sciences and Research Branch of Tehran, Islamic Azad University, Tehran, Iran
Mohammad Esmaeil Akbari
Affiliation:
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Nahid Nafisi
Affiliation:
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*
Correspondence to: Seied Rabi Mehdi Mahdavi, Department of Medical Physics, Iran University of Medical Sciences, 1449614525 Tehran, Iran. Tel: 982188622647. Fax: 982188622647. E-mail: [email protected]
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Abstract

Background

Intraoperative radiotherapy is a method of choice to deliver a critical radiation dose to the tumour bed immediately after surgical excision.

Aim

The purpose of this work is to check the dose delivered to the patients during intraoperative electron beam radiation therapy (IOERT) in the conservative treatment of breast cancer, by means of reference dose measurement using radiochromic (EBT-2) films.

Material and methods

Ninety patients with early-stage breast cancer underwent exclusive IOERT to the tumour bed using a LIAC linear accelerator. Absolute dose measurements were done with film pieces. After irradiation, the pixel values of the films were obtained via MATLAB and ImageJ softwares. Calibration curve was also used for calculating net optical density. Expected dose was compared to the patient delivered dose.

Results

The mean deviation of the delivered dose from the expected one was 2·56% that is well in the accepted criteria. Only in one case, there was a larger deviation due to barometer miscalibration.

Findings

EBT-2 film response is independent from dose-per-pulse and as it was shown in this study it can be robustly used during breast IOERT for dosimetric and also positioning verifications.

Keywords

breast cancerintraoperative radiotherapyin vivo dosimetryradiochromic EBT-2 films
Type
Original Articles
Information
Journal of Radiotherapy in Practice , Volume 15 , Issue 4 , December 2016 , pp. 378 - 384
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Copyright
© Cambridge University Press 2016 

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