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Impact of dose calculation algorithms on the dosimetric and radiobiological indices for lung stereotactic body radiotherapy (SBRT) plans calculated using LQ–L model

Published online by Cambridge University Press:  02 April 2018

Kashmiri L. Chopra ,
D. V. Rai ,
Anil Sethi ,
Jaiteerth S. Avadhani  and
T. S. Kehwar
Kashmiri L. Chopra
Affiliation:
Department of Biomedical Engineering, Shobhit University, Gangoh, UP, India
D. V. Rai
Affiliation:
Department of Biomedical Engineering, Shobhit University, Gangoh, UP, India
Anil Sethi
Affiliation:
Department of Radiation Oncology, Loyola University Medical Center, Maywood, IL, USA
Jaiteerth S. Avadhani
Affiliation:
Department of Radiation Oncology, Sr. Caritas Cancer Center, Springfield, MA, USA
T. S. Kehwar*
Affiliation:
Department of Radiation Oncology, Eastern Virginia Medical School, Sentara Obici Hospital, Suffolk, VA, USA
*
Correspondence to: T. S. Kehwar, Department of Radiation Oncology, Eastern Virginia Medical School, Sentara Obici Hospital, 1123 W Powderhorn Road, Mechanicsburg, PA 17050, USA. Tel: 001 724 557 9982. E-mail: [email protected]
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Abstract

Purpose

To investigate discrepancies in dose calculation algorithms used for lung stereotactic body radiotherapy (SBRT) plans.

Methods and materials

In total, 30 patients lung SBRT treatment plans, initially generated using BrainLab Pencil Beam (BL_PB) algorithm for 10 Gy×5 Fractions to the planning target volume (PTV) were included in the study. These plans were recalculated using BrainLab Monte Carlo (BL_MC), Eclipse AAA (EC_AAA), Eclipse Acuros XB (EC_AXB) and ADAC Pinnacle CCC (AP_CCC) algorithms. Dose volume histograms of PTV were used to calculate dosimetric and radiobiological quality indices, and equivalent dose to 2 Gy per fraction using linear-quadratic-linear model. The BL_MC algorithm is considered gold standard tool to compare PTV parameters and quality indices to investigate dose calculation discrepancies of abovementioned plans.

Results

BL_PB overestimates doses that may be due to inability of the algorithm to properly account for electron scattering and transport in inhomogeneous medium. Compared with BL_MCNO plans, the EC_AAA and EC_AXB yield lower homogeneity indices and overestimate the dose in the penumbra region, whereas AP_CCC plans were comparable for small PTV (≈8 cc) and had significant difference for large PTV.

Conclusion

BL_PB algorithm overestimates PTV doses than BL_MC calculated doses. The EC_AAA, EC_AXB and AP_CCC algorithms calculate doses within acceptable limits of radiotherapy dose delivery recommendations.

Keywords

lung SBRTLQ–L modelPTV parametersquality indices
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 17 , Issue 2 , June 2018 , pp. 219 - 229
Copyright
© Cambridge University Press 2018 

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