Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-23T15:55:42.972Z Has data issue: false hasContentIssue false

Dermatofibrosarcoma protruberans of the scalp treated with customised surface mould high-dose-rate (HDR) brachytherapy: a case report

Published online by Cambridge University Press:  18 June 2018

Anis Bandyopadhyay*
Affiliation:
Department of Radiotherapy, Medical College Kolkata, Kolkata, West Bengal, India
Poulami Basu
Affiliation:
Department of Radiotherapy, Medical College Kolkata, Kolkata, West Bengal, India
Somrita Biswas
Affiliation:
Department of Radiotherapy, Medical College Kolkata, Kolkata, West Bengal, India
Sandip Ghosh
Affiliation:
Medical Physics Unit, Department of Radiotherapy, Medical College Kolkata, Kolkata, West Bengal, India
*
Author for correspondence: Dr Anis Bandyopadhyay, Department of Radiotherapy, Medical College Kolkata, Room no. 15, 88B College Street, Kolkata, West Bengal, 700073, India. Tel: +91 9674142260. E-mail: [email protected]

Abstract

Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive soft tissue tumor commonly occurring in the trunk or extremities, lesser than 5% being located on the scalp. Surgery is the mainstay of management of this locally infiltrative cutaneous soft tissue sarcoma, with a high probability of recurrence if margin remains positive or inadequate. Adjuvant radiotherapy to a dose of 40–60 Gy decreases this chance of recurrence considerably. Radiotherapy is generally delivered by interstitial HDR brachytherapy, opposed photon or electron beam. We report a case of a 24 year old female, presenting with a small, painless nodule over right frontal area of scalp, diagnosed as DFSP post surgery with close margin that was treated with adjuvant radiation customized HDR surface mould brachytherapy with good local control and cosmesis.

Type
Case Study
Copyright
© Cambridge University Press 2018 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Loss, L, Zeitouni, N C. Management of scalp dermatofibrosarcoma protuberans. Dermatol Surg 2005; 31: 14281433.Google Scholar
2. Taylor, H B, Helwig, E B. Dermatofibrosarcoma protuberans. Cancer 1961; 15: 717725.Google Scholar
3. Kutzner, H. Expression of the human progenitor cell antigen CD34 (HPCA-1) distinguishes dermatofibrosarcoma protuberans from fibrous histiocytoma in formalin-fixed, paraffin-embedded tissue. J Am Acad Dermatol 1993; 28: 613617.Google Scholar
4. Ratner, D, Thomas, C O, Johnson, T M et al. Mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans. Results of a multiinstitutional series with an analysis of the extent of microscopic spread. J Am Acad Dermatol 1997; 37: 600613.Google Scholar
5. Kahn, LB, Saxe, N, Gordon, W. Dermatofibrosarcoma protuberans with lymph node and pulmonary metastases. Arch Dermatol 1978; 114 (4): 599601.Google Scholar
6. Sun, L M, Wang, CJ, Huang, CC et al. Dermatofibrosarcoma protuberans: treatment results of 35 cases. Radiother Oncol 2000; 57 (2): 175181.Google Scholar
7. Saiag, P, Grob, JJ, Lebbe, C et al. Diagnosis and treatment of dermatofibrosarcoma protuberans. European consensus-based interdisciplinary guideline. Eur J Cancer 2015; 51 (17): 26042608.Google Scholar
8. Mark, R J, Bailet, J W, Tran, L M et al. Dermatofibrosarcoma protuberans of the head and neck: a report of 16 cases. Arch Otolaryngol Head Neck 1993; 119: 891896.Google Scholar
9. Huether, M J, Zitelli, J A, Brodland, D G. Mohs micrographic surgery for the treatment of spindle cell tumors of the skin. J Am Acad Dermatol 2001; 44: 656659.Google Scholar
10. Parker, T L, Zitelli, J A. Surgical margins for excision of dermatofibrosarcoma protuberans. J Am Acad Dermatol 1995; 32 (2 Pt 1): 233236.Google Scholar
11. Haas, R L, Keus, R B, Loftus, B M, Rutgers, E J, van Coevorden, F, Bartelink, H. The role of radiotherapy in the local management of dermatofibrosarcoma protuberans. Soft Tissue Tumours Working Group. Eur J Cancer 1997; 33: 10551060.Google Scholar
12. Chen, Y T, Tu, W T, Lee, W R, Huang, Y C. The efficacy of adjuvant radiotherapy in dermatofibrosarcoma protuberans : a systemic review and meta-analysis. J Eur Acad Dermatol Venerol 2016; 30 (7): 11071114.Google Scholar
13. Safigholi, H, Song, W H, Meigooni, A S. Optimum radiation source for radiation therapy of skin cancer. J Appl Clin Med Phys 2015; 16 (5): 219227.Google Scholar
14. Guix, B, Finestres, F, Tello, J et al. Treatment of skin carcinomas of the face by high dose rate brachytherapy and custom made surface molds. Int J Radiat Oncol Biol Phys 2000; 47: 95102.Google Scholar
15. Delishaj, D, Rembielak, A, Manfredi, B et al. Non-melanoma skin cancer treated with high-dose-rate brachytherapy: a review of literature. J Contemp Brachytherapy 2016; 8 (6): 533540.Google Scholar
16. Alektiar, K M, Leung, D, Zelefsky, M J, Healey, J H, Brennan, M F. Adjuvant brachytherapy for primary high-grade soft tissue sarcoma of the extremity. Ann Surg Oncol 2002; 9: 4856.Google Scholar
17. Pisters, P W T, O’Sullivan, B, Maki, R G. Evidence-based recommendations for local therapy for soft tissue sarcomas. J Clin Oncol 2007; 25: 10031008.Google Scholar
18. Alekhteyar, K M, Leung, D H, Brennan, M F, Harrison, L B. The effect of combined external beam radiotherapy and brachytherapy on local control and wound complications in patients with high-grade soft tissue sarcomas of the extremity with positive microscopic margin. Int J Radiat Oncol Biol Phys 1996; 36: 321324.Google Scholar
19. Ozyar, E, Gurdalli, S. Mold brachytherapy can be an optional technique for total scalp irradiation. Int J Radiat Oncol Biol Phys 2002; 54: 1286.Google Scholar
20. Evans, M D C, Yassa, M, Podgorsak, E B, Schreiner, LJ, Souhami, L. Surface applica-tors for high dose rate brachytherapy in aids-related Kaposı sarcoma. Int J Radiat Oncol Biol Phys 1997; 39: 769774.Google Scholar
21. Sanada, T, Nakamaya, H, Irisawa, R, Okubo, M, Tsuboi, R, Tokuuye, K. Clinical outcome and dose volume evaluation in patients who undergo brachytherapy for angiosarcoma of the scalp and face. Mol Clin Oncol 2017; 6: 334340.Google Scholar
22. Mukherji, A, Sinnatamby, M. Malignant soft tissue sarcoma of the shoulder treated by surface mould brachytherapy boost in an adjuvant setting. J Contemp Brachytherapy 2017; 9 (2): 167173.Google Scholar