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The use of Glucagon in the Termination of Insulin Coma

Published online by Cambridge University Press:  08 February 2018

M. J. Cosgrave  and
M. C. Moss
M. J. Cosgrave
Affiliation:
Hospital Medical Officer Deva Hospital, Chester
M. C. Moss
Affiliation:
Deva Hospital, Chester
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Extract

Glucagon, the hyperglycaemic glycogenolytic factor of the pancreas, was discovered by Kimball and Murlin in 1923 (1). It was crystallized by Staub, Sinn and Behrens in 1953 (2, 3). Glucagon is believed to cause a rise in blood sugar by acting at the site of liver Phosphorylase—converting inactive Phosphorylase to active Phosphorylase (4).

Type
Original Articles
Information
Journal of Mental Science , Volume 107 , Issue 447 , March 1961 , pp. 294 - 296
Copyright
Copyright © Royal College of Psychiatrists, 1961 

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References

1. Kimball, C. P., and Murlin, J. R., “Aqueous Extracts of Pancreas. Some Precipitation Reactions of Insulin”, J. Biol. Chem., 1923, 58, 337–346.Google Scholar
2. Staub, A., Sinn, L., and Behrens, O. K., “Purification and Crystallization of Hypoglycaemic Glycogenolytic Factor (H.G.F.)”, Science, 1953, 117, 628–629.Google Scholar
3. Iidem , “Purification and Crystallization of Glucagon”, J. Biol. Chem., 1955, 214, 619–632.Google Scholar
4. Sutherland, E. W., and Cori, C. F., “Influence of Insulin Preparations on Glycogenosis in Liver Slices”, J. Biol. Chem., 1948, 172, 737.Google Scholar
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