In opening this subject, I wish to give first a few preliminary words of explanation. The object of this paper is to raise the points germane to the organisation of research. Organisation, to my mind, is the most important point in research, and the only foundation upon which successful investigation can rest. Anything which follows will be clearly understood to be merely an opinion expressed in order to open discussion and invite free criticism. The illustrations given of the difficulties attending investigation in our subject are nothing more than examples: they are not meant to be regarded as definite lines along which research should be conducted, but rather to be read in the sense of evidence brought forward in favour of a serious and co-ordinated effort on the part of those who would attempt to discover the pathogenesis of morbid psychology and neurology.