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The Significance of Cholesterol in Cellular Oxidation and Its Bearing On Mental Disorder

Published online by Cambridge University Press:  19 February 2018

B. H. Shaw  and
J. S. Sharpe
B. H. Shaw
Affiliation:
County Mental Hospital, Stafford
J. S. Sharpe
Affiliation:
County Mental Hospital, Stafford
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Extract

Sterols, such as cholesterol, phytosterol, etc., are present in all animal and vegetable tissues, and play a most important rôle in physiological and pathological processes. For example, it is well known that cholesterol has a powerful influence in aiding complement fixation in sero-diagnosis—it checks the action of lipolytic enzymes and inhibits the hæmolytic action of saponins and cobra venom on erythrocytes. It is an important factor in giving cells their power of holding large quantities of water without losing their peculiar semi-fluid characters and without dissolving. Citron (1) states that 1 c.c. of an emulsion of central nervous system neutralizes three times the fatal dose for mice of botulism toxin and that lecithin and cholesterol act similarly.

Type
Part I.—Original Articles
Information
Journal of Mental Science , Volume 77 , Issue 316 , January 1931 , pp. 53 - 66
Copyright
Copyright © Royal College of Psychiatrists, 1931 

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References

1 Citron, J., Immunity. Google Scholar
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9 Okada, S., “Action of Cholesterol and Lecithin on the Golgi Apparatus,” Arb. Med. Univ. Okayama, 1930; Akiyama, S., “A Histological Study of Nerve Cells which have been Submitted to the Action of Cholesterol, Lecithin, Calcium and Potassium Respectively,” ibid., 1930.Google Scholar
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