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Sedation Threshold, Personality, and the Theory of Neurosis

Published online by Cambridge University Press:  08 February 2018

G. S. Claridge  and
R. N. Herrington
G. S. Claridge
Affiliation:
Institute of Psychiatry (Maudsley Hospital), University of London
R. N. Herrington
Affiliation:
Royal Victoria Hospital, Netley
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Extract

For many years it has been observed that individuals differ in their tolerance of depressant drugs. In everyday life differential susceptibility to the effects of alcohol is that most commonly observed and this fact led to McDougall's early theorizing (1929) about drug tolerance and personality. Also at this time Pavlov, in dogs, recorded differences in drug sensitivity in his various temperamental types. However, the first attempt to measure individual differences in drug tolerance was made by Shagass (1954), who proposed the concept of “sedation threshold”. This was defined in terms of the amount of sodium amytal required to bring about certain behavioural and other changes in the individual, the threshold itself lying somewhere between the state of complete wakefulness and that of complete sedation. Two methods of determining the threshold were employed by Shagass. First, the point of onset of slurred speech gave an approximate estimate of its position. Secondly, a more accurate determination was made by means of EEG changes, specifically the point at which inflexion occurs in the amplitude curve of induced fast frontal activity.

Type
Original Articles
Information
Journal of Mental Science , Volume 106 , Issue 445 , October 1960 , pp. 1568 - 1583
Copyright
Copyright © Royal College of Psychiatrists, 1960 

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References

Ackner, B., and Pampiglione, G., “Discussion on physiological measurements of ‘emotional tension’”, Proc. Roy. Soc. Med., 1958, 51, 76–81.Google Scholar
Arduini, A., and Arduini, M. G., “Effect of drugs and metabolic alterations on brainstem arousal mechanism”, J. Pharm. Exper. Therap., 1954, 110, 76.Google Scholar
Bradley, P. B., and Elkes, J., “The effect of some drugs on the electrical activity of the brain”, Brain, 1957, 80, 77–117.CrossRefGoogle Scholar
Broadbent, D. E., Perception and Communication, 1958. London: Pergamon Press.Google Scholar
Claridge, G. S., “The excitation-inhibition balance in neurotics”, in: Eysenck, H. J. (Ed.), Experiments in Personality (2 vols.), 1960a. London: Routledge ' Kegan Paul.Google Scholar
Idem , “The effects of meprobamate on the performance of a five-choice serial reaction time task”, 1960b. Submitted for publication.Google Scholar
Idem , “Arousal and inhibition as determinants of the performance of neurotics”. To appear. Dell, P. C., “Some basic mechanisms of the translation of bodily needs into behaviour”, in: The Neurological Basis of Behaviour, 1958. Ciba Symposium.Google Scholar
Duffy, E., “The psychological significance of the concept of ‘arousal’ or ‘activation”’, Psychol. Rev., 1957, 64, 265–275.Google Scholar
Eccles, J. C., The Physiology of Nerve Cells, 1958. Oxford: Clarendon Press.Google Scholar
Eysenck, H. J., The Structure of Human Personality, 1953. London: Methuen.Google Scholar
Idem , “A dynamic theory of anxiety and hysteria”, J. Ment. Sci., 1955, 101, 28–51.Google Scholar
Idem , “Drugs and personality: I. Theory and methodology”, ibid., 1957a, 103, 119–131.Google Scholar
Idem , The Dynamics of Anxiety and Hysteria, 1957b. London: Routledge ' Kegan Paul.Google Scholar
French, J. D., Verzeano, M., and Magoun, H. W., “A neural basis for the anaesthetic state”, Arch. Neurol. and Psychiat. (Chicago), 1953, 69, 519.Google Scholar
Gellhorn, E., Autonomic Imbalance and the Hypothalamus, 1957. Minneapolis: University of Minnesota Press.Google Scholar
Hebb, D. O., “Drives and the CNS (Conceptual Nervous System)”, Psychol. Rev., 1955, 62, 243–254.Google Scholar
Kimble, G. A., “An experimental test of a two-factor theory of inhibition”, J. exp. Psychol., 1949, 39, 15–23.CrossRefGoogle Scholar
King, E. E., “Differential action of anaesthetics and interneuron depressants on EEG arousal and recruiting responses”, J. Pharm. and Exper. Therap., 1956, 116, 404.Google Scholar
Laverty, S. G., “Sodium amytal and extraversion”, J. Neurol. Neurosurg. Psychiat., 1958, 21, 50–54.Google Scholar
Lindsley, D. B., “Emotion”, in: Stevens, S. S. (Ed.), Handbook of Experimental Psychology, 1951. London: Chapman ' Hall.Google Scholar
Malmo, R. B., “Anxiety and behavioural arousal”, Psychol. Rev., 1957, 64, 276–287.CrossRefGoogle Scholar
Idem , “Activation: a neuropsychological dimension”, ibid., 1959, 66, 367–386.Google Scholar
McDougall, W., “The chemical theory of temperament applied to introversion and extraversion”, J. abn. soc. Psychol., 1929, 24, 293–309.CrossRefGoogle Scholar
Nymgaard, K., “Studies on the sedation threshold. A. Reproducibility and effect of drugs. B. Sedation threshold in neurotic and psychotic depression”, Arch. Gen. Psychiat., 1959, 1, 530–536.Google Scholar
Pavlov, I. P., “Experimental pathology of the higher nervous activity”, in: Selected Works, 1955. Moscow: Foreign Languages Publishing House.Google Scholar
Shagass, C., “The sedation threshold. A method for estimating tension in psychiatric patients”, EEG clin. Neurophysiol., 1954, 6, 221–233.Google Scholar
Idem , “Neurophysiological studies of anxiety and depression”, A.P.A. Psychiat. Res. Reports, 1958, 8.Google Scholar
Idem and Jones, A. L., “A neurophysiological test for psychiatric diagnosis: results in 750 patients”, Amer. J. Psychiat., 1958, 114, 1002–9.Google Scholar
Idem, and Kerenyi, A. B., “Neurophysiologic studies of personality”, J. Nerv. Ment. Dis., 1958, 126, 141–147.Google Scholar
Idem, and Naiman, J., “The sedation threshold, manifest anxiety, and some aspects of ego function”, Arch. Neurol. and Psychiat., 1955, 74, 397–406.Google Scholar
Iidem , “The sedation threshold as an objective index of manifest anxiety in psychoneurosis”, J. Psychosom. Res., 1956, 1, 49–57.Google Scholar
Sigal, J. J., Star, K. H., and Franks, C. M., “Hysterics and dysthymics as criterion groups in the study of introversion-extraversion”, J. abnorm. soc. Psychol., 1958, 57, 143–148.Google Scholar
Thorpe, J. G., and Barker, J. C., “Objectivity of the sedation threshold”, Arch. Neurol. Psychiat., 1957, 78, 194–196.Google Scholar
van der Merwe, A. B., “The diagnostic value of peripheral vasomotor reactions in the psychoneuroses”, Psychosom. Med., 1948, 10, 347–354.Google Scholar
Venables, P. H., “Factors in the motor behaviour of functional psychotics”, J. abnorm. soc. Psychol., 1959, 58, 153–156.Google Scholar
Weil-Malherbe, H., “The concentration of adrenaline in human plasma and its relation to mental activity”, J. Ment. Sci., 1955, 101, 733–755.Google Scholar
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