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Remarks on the Giant-cells of the Motor Cortex in the Insane, examined in a fresh state (without hardening). A Contribution to the Pathology of the Nerve-cell

Published online by Cambridge University Press:  19 February 2018

John Turner
John Turner*
Affiliation:
County Asylum, Brentwood, Essex
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Extract

Introduction.—In these days of elaborate technique, it may not be without interest to record a method which enables us to demonstrate details of structure in the nerve-cells which have been practically untampered with by hardening fluids or other reagents.

Type
Part I.—Original Articles
Information
Journal of Mental Science , Volume 44 , Issue 186 , July 1898 , pp. 507 - 526
Copyright
Copyright © Royal College of Psychiatrists, 1898 

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References

Reference to Figures

* Read at the General Meeting, 12th May, 1898.Google Scholar
* Text-book of Mental Diseases, p. 473.Google Scholar
† Term used in the last edition of Foster's Physiology to denote the body of the cell surrounding the nucleus.Google Scholar
* Berger (Monatsschrift für Psych, und Neur., January, 1898) figures similar cells from the ventral horn in cases of general paralysis.Google Scholar
* Vide Barker, , Brit. Med. Journ., Dec. 25th, 1897; Dehrio, H., Centralbl. für Nervenheilkunde und Psychiatrie, 1895, N. F., vi, 113; Stewart, C. C., Med. Pioneer, August, 1897.Google Scholar
Reference to Figures.Google Scholar
1. —Normal nerve-cell (69 × 57 μ, nucleolus 5 × 6 μ), showing the arrangement of chromophilic material in the perikaryon and apex, and the numerous dendrites with fine threads. From a woman aged 59. Chronic melancholia.Google Scholar
2. —Granular degeneration of the chromophilic material, from the same case as above. In the apex the threads are seen to be broken up into linearly arranged segments. The perikaryon measures 99 × 49 μ. The nucleus (17 × 12 μ) is deeply stained, and with clusters of granules around its margin. The nucleolus measures 6 μ .Google Scholar
3. —Large (? swollen) cell (210 × 83 μ) stained of a pale, dull, uniform blue, and showing no trace of chromophilic material, either in perikaryon or processes; the nucleus is dimly visible, and centrally situated; the nucleolus measures 10 μ. The apex breaks up into a pale, fan-shaped expansion. From a case of puerperal mania aged 25.Google Scholar
4. —Dark, irregularly-stained cell (90 × 63 μ), showing the pale, ill-defined, ragged apex, and peripherally situated nucleolus (8 × 5 μ) surrounded by a paler zone. The processes are few, show no chromatin, and curl upon themselves when detached from their matrix. From a case of secondary dementia in a man aged 56.Google Scholar
5. —Cell with normal arrangement of chromatin, showing a leucocyte destroying the apex.Google Scholar
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