Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-18T12:17:34.987Z Has data issue: false hasContentIssue false
  • English
  • Français

Purines in the Urine of Normal and Schizophrenic Subjects

Published online by Cambridge University Press:  08 February 2018

Brenda M. Bollard ,
R. H. Culpan ,
N. Marks ,
H. McIlwain  and
Michael Shepherd
Brenda M. Bollard
Affiliation:
Departments of Biochemistry and Psychiatry, Institute of Psychiatry (British Postgraduate Medical Federation, University of London) Maudsley Hospital, London, S.E.5
R. H. Culpan
Affiliation:
Departments of Biochemistry and Psychiatry, Institute of Psychiatry (British Postgraduate Medical Federation, University of London) Maudsley Hospital, London, S.E.5
N. Marks
Affiliation:
Departments of Biochemistry and Psychiatry, Institute of Psychiatry (British Postgraduate Medical Federation, University of London) Maudsley Hospital, London, S.E.5
H. McIlwain
Affiliation:
Departments of Biochemistry and Psychiatry, Institute of Psychiatry (British Postgraduate Medical Federation, University of London) Maudsley Hospital, London, S.E.5
Michael Shepherd
Affiliation:
Departments of Biochemistry and Psychiatry, Institute of Psychiatry (British Postgraduate Medical Federation, University of London) Maudsley Hospital, London, S.E.5
Get access Rights & Permissions [Opens in a new window]

Extract

Although there have been many attempts to discover in the body fluids, chemical peculiarities characteristic of schizophrenic illness, the outcome of most of these investigations has been inconclusive (see for example Altschule, 1953; Kety, 1959). Little attention has been paid, however, to purine metabolism until the recent studies of Kishimoto (1958) who reported peculiarities in the absorption spectra of body fluids in schizophrenia which he attributed to abnormalities in the conversion of adenine through hypoxanthine and xanthine to uric acid. These findings appeared to be supported by evidence which included the determination of urinary xanthine by a xanthine oxidase method based on that of Williams (1950).

Type
Original Articles
Information
Journal of Mental Science , Volume 106 , Issue 445 , October 1960 , pp. 1250 - 1272
Copyright
Copyright © Royal College of Psychiatrists, 1960 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Albert, A., Quart. Rev. Chem. Soc., 1952, 6, 197.CrossRefGoogle Scholar
Altschule, M. D., Body Physiology in Mental and Emotional Disorders, 1953. New York: Grune ' Stratton.Google Scholar
Beard, H. H., Creatine and Creatinine Metabolism, 1943. London: Chapman ' Hall.Google Scholar
Christman, A. D., Physiol. Rev., 1952, 32, 303.Google Scholar
Folin, O., Amer. J. Physiol., 1905, 13, 66.Google Scholar
Hunter, A., Creatine and Creatinine, 1928. London: Longmans Green.Google Scholar
Kety, S. S., Science, 1959, 129, 1528, 1590.CrossRefGoogle Scholar
Kishimoto, K., Chromatographic Techniques, 1958. London: Heinemann.Google Scholar
Sollmann, T., Pharmacology, 1957. London: Saunders.Google Scholar
Vestergaad, P., and Leverett, R., J. Lab. Clin. Med., 1958, 51, 211.Google Scholar
Weissmann, B., Bromberg, P. A., and Gutman, A. B., J. biol. Chem., 1957, 224, 407, 423.Google Scholar
Idem and Gutman, A. B., ibid., 1957, 229, 239.Google Scholar
Williams, J. N. Jr., ibid., 1950, 187, 47.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.