We have ventured to bring forward the following case for various reasons. The first is the unusual distribution of the lesions found post-mortem, namely, in the supra-renal capsules and the pituitary body. The second is that during life the clinical features of the case were not sufficiently pronounced unmistakably to suggest any affection of the parts shown to be diseased at the necropsy. The third and most important consideration is that a narration of the facts raises the question of the significance of pathological changes in the ductless glands in the insane.