Hostname: page-component-745bb68f8f-cphqk Total loading time: 0 Render date: 2025-01-09T22:56:24.053Z Has data issue: false hasContentIssue false
  • English
  • Français

A Pilot Trial of Orphenadrine (“Disipal”) in Patients Treated with Reserpine

Published online by Cambridge University Press:  08 February 2018

G. E. Langley  and
A. A. Robin
G. E. Langley
Affiliation:
Runwell Hospital, Wickford, Essex
A. A. Robin
Affiliation:
Runwell Hospital, Wickford, Essex
Get access Rights & Permissions [Opens in a new window]

Extract

β-Dimethylamine ethyl 2-methylbenzhydryl ether hydrochloride (Orphenadrine, “Disipal”) is a synthetic substance closely resembling in chemical structure the antihistamine dephenhydramine (“Benadryl”). It was developed in Holland (Harms, 1957) for use in parkinsonism and in this context reported upon favourably in this country by Gillhespy and Ratcliffe (1956). Claims have also been made that the drug is (i) effective in treating the pseudo-parkinsonism produced by reserpine, (ii) active in alleviating other (e.g. autonomic or vasomotor) side-effects of reserpine, (iii) has independent “psychic” activity, or (iv) enhances the tranquillizing effect of reserpine (Frieswinkel, 1957a, 1957b; Van Rhijn, 1957; Meulenbeld, 1957; Scheurle, 1957). The following trial is designed to assess some of these claims.

Type
Original Articles
Information
Journal of Mental Science , Volume 106 , Issue 443 , April 1960 , pp. 682 - 685
Copyright
Copyright © Royal College of Psychiatrists, 1960 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Arnold, A. L., and Freeman, H., Arch. Neurol. Psychiat., 1956, 76, 281.Google Scholar
Barsa, J. A., and Kline, N. S., ibid., 1956, 76, 90.Google Scholar
Elkes, C., J. Ment. Sci., 1957, 103, 464.Google Scholar
Frieswinkel, H., Disipal Symposium, 1957a. Amersfoort: Brocades, p. 57.Google Scholar
Idem , Die Therapie des Monats, 1957b, 5, 162.Google Scholar
Gillhespy, R. O., and Ratcliffe, A. H., Bgham. med. Rev., 1956, 19, 115.Google Scholar
Harms, A. F., Disipal Symposium, 1957. Amersfoort: Brocades, p. 6.Google Scholar
Koltanow, L., J. Nerv. Ment. Dis., 1956, 123, 392.Google Scholar
Kovrrz, B., et al., Arch. Neurol. Psychiat., 1955, 74, 467.Google Scholar
Lucero, R. J., and Meyer, B. T., J. Clin. Psychol., 1951, 7, 250.Google Scholar
Meulenbeld, G. J., Disipal Symposium, 1957. Amersfoort: Brocades, p. 75.Google Scholar
Naidoo, D., J. Nerv. Ment. Dis., 1956, 123, 1.Google Scholar
Scheurle, G., Deutsche medizinische Wochenschrift, 1957, 82, 227.Google Scholar
Van Rhijn, C. H., Disipal Symposium, 1957. Amersfoort: Brocades, p. 66.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.