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Physiological Effects of Schizophrenic Body Fluids

Published online by Cambridge University Press:  08 February 2018

Edith G. McGeer  and
Patrick L. McGeer
Edith G. McGeer
Affiliation:
From the Department of Neurological Research, University of British Columbia, Vancouver, Canada
Patrick L. McGeer
Affiliation:
From the Department of Neurological Research, University of British Columbia, Vancouver, Canada
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Extract

Controversy has raged for over half a century as to whether schizophrenia, the most severe of all mental illnesses, could have an organic basis or whether its origin lay strictly in the psyche. Over the years, physiologists have probed into almost every aspect of the soma in the quest for some abnormality which would account for the schizophrenic syndrome. Many possibilities have been considered, investigated to a degree and then abandoned when definitive answers were not forthcoming. A dominant approach throughout has been the search for some psychotoxic material circulating in schizophrenic body fluids. Activity has been spurred by the recurrent recognition that chemical agents such as the ergot alkaloids, mescaline, bulbocapnine and lysergic acid diethylamide (LSD-25), could induce in normal persons transient mental disturbances similar to those seen in schizophrenia.

Type
Original Articles
Information
Journal of Mental Science , Volume 105 , Issue 438 , January 1959 , pp. 1 - 18
Copyright
Copyright © Royal College of Psychiatrists, 1959 

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References

1. Abely, X., et al., Ann. Méd.-Psychol., 1932, 90, 170.Google Scholar
2. Altschule, M. D., et al., Arch. Neurol. Psychiat., 1950, 44, 641; J. Ment. Sci., 1951, 97, 405.CrossRefGoogle Scholar
3. Idem, A.M.A. Arch. Int. Med., 1956, 98, 35.CrossRefGoogle Scholar
4. Baldi, F., Neurologica, 1926, 43, 91.Google Scholar
5. Baruk, H., and Camus, L., Presse Méd., 1949, 1065; ibid., 1933, 41, 1588, 1967; Ann. Méd.-Psychol., 1934, 92, 646, 647, 711; Compt. rend. soc. biol., 1934, 116, 27, 29, 136, 403, 405.Google Scholar
6. Idem, J. Nerv. and Ment. Dis., 1949, 110, 218.CrossRefGoogle Scholar
7. Becher, E., Münch. med. Wochenschr., 1928, 75, 465.Google Scholar
8. Berger, H., Berliner klin. Wochenschr., 1903, 40, 693; Monatschr. f. Psychiat. u. Neurol., 1904, 16, 1, 213.Google Scholar
9. Bond, D. D., Amer. J. Psychiat., 1958, 114, 919.Google Scholar
10. Bouchard, , 1887, cited by Juschtschenko, Das Wesen der Geisteskrankheiten, 1914.Google Scholar
11. Bulle, P. H., and Konchegul, L., J. Clin. Exptl. Psychopath., 1957, 18, 287.Google Scholar
12. Buscaino, V. M., Riv. Pat. nerv. ment., 1929, 34, 162.Google Scholar
13. Idem, ibid., 1922, 27, 178; ibid., 1924, 29, 501; L'Encéphale, 1930, 25, 48.Google Scholar
14. Claude, H., et al., Ann. Méd.-Psychol., 1932, 90, 617.Google Scholar
15. Idem, Compt. rend. soc. biol., 1939, 130, 531.Google Scholar
16. De Jong, H. H., Experimental Catatonia, 1945. Williams & Wilkins Co.Google Scholar
17. Idem, Acta Brevia Need., 1938, 111, 148.Google Scholar
18. Idem, Ann. Méd.-Psychol., 1934, 92, 131; ibid., 1933, 91, 149.Google Scholar
19. De Nigris, G., and Mariani, G., Neuropsichiatria, 1936, 14, 444, 633.Google Scholar
20. Dide, M., and Aujaleu, P., Compt. rend. soc. biol., 1934, 116, 422.Google Scholar
21. Dingemanse, E., et al., Zeit. f. d. ges. Neurol. u. Psychiat., 1933, 143, 456.Google Scholar
22. Idem and Freud, J., Acta Brevia Neerl. Physiol., Pharmacol., Microbiol., 1933, 3, 49; Chem. Abstracts, 1933, 27, 4309.Google Scholar
23. Dussik, K., Th., and Pichler, E., Klin. Wochenschr., 1938, 17, 509.CrossRefGoogle Scholar
24. Edisen, C. B., Dis. Nerv. Syst. (Galveston), 1956, 17, 77.Google Scholar
25. Eppinger, H. O., Wien. klin. Wochenschr., 1940, 53, 372.Google Scholar
26. Evans, T. L., et al., Science, 1956, 123, 26.CrossRefGoogle Scholar
27. Fabing, H. D., Neurology, 1955, 5, 603.CrossRefGoogle ScholarPubMed
28. Idem , Amer. Fed. Meeting, April, 1956, Abstract No. 1311.Google Scholar
29. Federoff, S., Texas Repts. Biol. and Med., 1958, 16, 32.Google Scholar
30. Idem, J. Lab. and Clin. Med., 1956, 48, 55.Google Scholar
31. Idem and Cook, B., Proc. Canad. Fed. Biol. Soc., 1958, 9–11 June.Google Scholar
32. Idem and Hoffer, A., J. Nerv. and Ment. Dis., 1956, 124, 396.Google Scholar
33. Fischer, R., Science, 1953, 118, 409.CrossRefGoogle ScholarPubMed
34. Idem, Science, 1954, 120, 505.CrossRefGoogle Scholar
35. Idem, Canad. Med. Assoc. J., 1956, 74, 461; Naturwissen., 1955, 42, 301.Google Scholar
36. Freeman, W., and Looney, J. M., Arch. Neurol. and Psychiat., 1934, 32, 554.CrossRefGoogle Scholar
37. Freud, J., and Dingemanse, E., Biochem. Z., 1932, 255, 464.Google Scholar
38. Gaberman, P., J. Lab. and Clin. Invest., 1951, 37, 544.Google Scholar
39. Gamper, E., and Kral, A., Zeit. f. d. ges. Neurol. u. Psychiat., 1934, 150, 252.CrossRefGoogle Scholar
40. Idem, ibid., 1933, 146, 567; ibid., 1935, 153, 258; ibid., 1937, 159, 697.Google Scholar
41. Gamper, E., et al., ibid., 1932, 140, 789; ibid., 1932, 141, 689; Arch. f. Psychiatr., 1932 97, 678.Google Scholar
42. Georgi, F., et al., Science, 1954, 120, 504; Monatsch. f. Psych. u. Neurol., 1954, 128.CrossRefGoogle Scholar
43. Idem and Rieder, H. P., Acta anat., Basel, 1957, 30, 286.Google Scholar
44. Goldblatt, H., and Krapewkin, A., Psychiat.-Neurol. Wochenschr., 1942, 34, 638; Ann. Med.-Psychol., 1933, 91, 280.Google Scholar
45. Goldner, M. G., and Ricketts, H. T., Arch. Neurol. and Psychiat., 1942, 48, 552.CrossRefGoogle Scholar
46. Gooszen, J. A. H., A Study of the Histamine Metabolism in Schizophrenia, 1951. Zuid-Nederlandse Drukkerij N.V.S.-Hertogenbosch., 73 pages.Google Scholar
47. Grimm, H., Forschung u. Fortschr., 1950, 26, 50; Zeit. f. Altersforschung, 1951, 5, 197.Google Scholar
48. Guilmot, P., Acta neurol. et psychiatr. belg., 1952, 52, 81.Google Scholar
49. Gullotta, S., Arch. f. Psychiat., 1930, 90, 436.CrossRefGoogle Scholar
50. Hall, G. E., et al., Amer. J. Psych., 1938, 95, 562.CrossRefGoogle Scholar
51. Harris, M. M., Arch. Neurol. and Psychiat., 1942, 48, 761.CrossRefGoogle Scholar
52. Heath, R. G., et al., A.M.A. Arch. Neurol. and Psychiat., 1956, 76, 444, 630.Google Scholar
53. Idem, Amer. J. Psychiat., 1957, 114, 14, 917.Google Scholar
54. Herz, E., and Weichbrodt, R., Deutsch. med. Wochenschr., 1924, 50, 1210.CrossRefGoogle Scholar
55. Hoffer, A., and Kenyon, M., A.M.A. Arch. Neurol. and Psychiat., 1957, 77, 437.CrossRefGoogle Scholar
56. Idem, et al., J. Ment. Sci., 1954, 100, 29.CrossRefGoogle Scholar
57. Idem , “Rept. on Dept. of Natl. Health and Welfare, Mental Health Grant, 1948–1955”, No. 607–5–165.Google Scholar
58. Holmes, B., and Retinger, J., Medical Record, 1916, 89, 815.Google Scholar
59. Horwitt, M. K., Science, 1956, 124, 429.CrossRefGoogle Scholar
60. Houssay, B. A., cited by Meduna and Vaichulis (74).Google Scholar
61. Hukuda, M. (Fukuda, M.), J. Kumamoto Med. Soc., 1936, 12, 1439, 1457.0Google Scholar
62. Jacobowsky, B., Acta Psych. Neurol. 1936, 11, 673.CrossRefGoogle Scholar
63. Juschtschenko, A. J. (Yushchenko, A. I.), Arch. f. psychiat., 1909, 45, 151.Google Scholar
64. Kastan, M., Arch. f. Psych. u. Nervenkrank., 1926, 78, 637.CrossRefGoogle Scholar
65. Kemali, D., and Buscaino, V. M., Acta Neurol. 1957, 13, 1179.Google Scholar
66. Lazell, E. W., and Prince, L. H., U.S. Vet. Bur. Med. Bull., 1929, 5, 40.Google Scholar
67. Le Grand, A., and Annee, P., Ann. Méd.-Psychol., 1939, 97, 306; Compt. rend. soc. biol., 1938, 128, 1139.Google Scholar
68. Leif, H. I., A.M.A. Arch. Neurol. and Psychiat., 1957, 78, 624.CrossRefGoogle Scholar
69. Loewe, S., Z. Neurol. Psychiat., 1911, 7, 73.CrossRefGoogle Scholar
70. Looney, J. M., et al., Amer. J. Med. Sci., 1939, 198, 528.CrossRefGoogle Scholar
71. McGeer, E. G., et al., J. Nerv. and Ment. Dis., 1957, 125, 176.CrossRefGoogle Scholar
72. Macht, D. I., et al., South Med. J., 1950, 43, 1049; J. Pharm. and Exptl. Therapy, 1924, 22, 413; Amer. Physiological Soc. Meeting, 1956, April. Abstract No. 397.CrossRefGoogle Scholar
73. Malis, G., Nevropat. i. Psikhiat., 1947, 16, 66.Google Scholar
74. Meduna, L. J., and Vaichulis, J. A., Dis. Nerv. Syst. (Galveston), 1948, 9, 248.Google Scholar
75. Idem, et al., Arch. Neurol. and Psychiat., 1942, 47, 38.CrossRefGoogle Scholar
76. Minz, B., and Walaszek, E. J., Compt. rend. Acad. Sci., 1957, 244, 1974.Google Scholar
77. Miyakawa, K., and Yamasita, K., J. Kumamoto Med. Soc., 1937, 13, 365.Google Scholar
78. Morgan, M. S., and Pilgrim, F. J., Proc. Soc. Exptl. Biol. Med., 1952, 79, 106.CrossRefGoogle Scholar
79. Moya, F., et al., Endocrinology, 1955, 57, 322.CrossRefGoogle Scholar
80. Idem, Canad. Physiological Soc. Meeting, 1956.Google Scholar
81. Idem, Canad. J. Biochem. and Physiology, 1956, 34, 563.CrossRefGoogle Scholar
82. Idem, ibid., 1958, 36, 505.Google Scholar
83. Nieuwenhuyzen, F. J., Proc. Akad. Sci., Amsterdam, 1934, 37, 575; ibid., 1938, 41, 304.Google Scholar
84. Idem, ibid., 1938, 41, 316; ibid., 1936, 39, 1151.Google Scholar
85. Persic, N., and Feric, F., Neuropsihijatrija, 1957, 5, 149.Google Scholar
86. Pfeffer, A. Z., and Pescor, M. J., A.M.A. Arch. Neurol. and Psychiat., 1944, 52, 131.CrossRefGoogle Scholar
87. Pfeiffer, H., and Albrecht, O., Z. Neurol. Psych., 1912, 9, 409.CrossRefGoogle Scholar
88. Idem and De Crinis, M., Z. ges. Neurol. 1914, 18, 428; Z. Immunitat., 1913, 18, 93.Google Scholar
89. Poloni, A., EEG and Clin. Neurophysiol., 1954, 6, 535.Google Scholar
90. Reiter, P. J., Zeit. f. d. ges. Neurol. u. Psychiat., 1938, 160, 598.CrossRefGoogle Scholar
91. Rieder, H. P., Confinia Neurol. 1954, 14, 65; Schweiz. Med. Wochenschr., 1953, 83, 1541; Schweiz. Arch. Neurol. u. Psychiat., 1953, 72, 387.CrossRefGoogle Scholar
92. Idem, Psychiat. et Neurol. 1957, 134, 378.CrossRefGoogle Scholar
93. Idem, Schweiz. Arch. Neurol. and Psychiat., 1957, 80, 347.Google Scholar
94. Rothlin, E., Nature, 1956, 178, 1400.CrossRefGoogle Scholar
95. Scheid, K. F., Zeit. f. d. ges. Neurol. u. Psychiat., 1937, 159, 694.CrossRefGoogle Scholar
96. Shapiro, A. K., J. Nerv. and Ment. Dis., 1956, 123, 65.CrossRefGoogle Scholar
97. Shiraishi, J., Igaku to Seibutsugaku, 1955, 36, 238; Chem. Abstracts, 1958, 52, 2240.Google Scholar
98. Sjovall, T., Acta Psych. and Neurol. Suppl., 1947, 47, 105.CrossRefGoogle Scholar
99. Smith, K., Amer. J. Psych., 1958, 114, 920.CrossRefGoogle Scholar
100. Idem and Moody, A. C., Dis. Nerv. Syst. (Galveston), 1956, 17, 327.Google Scholar
101. Sogliani, G., Cervello, 1938, 17, 253.Google Scholar
102. Sourkes, T. L., Canad. Med. Assoc. J., 1957, 77, 1135, “Rept. on 2nd Intern. Congr. on Psychiatry”, Zurich, September, 1957.Google Scholar
103. Streifler, M., and Kornbluth, W., Paper presented at Intern, Congr. on Psychiatry, Zurich, August, 1957.Google Scholar
104. Tinel, J., and Eck, M., Ann. Méd.-Psychol., 1933, 91, 710.Google Scholar
105. Tomesco, P., et al., Bull. de la Soc. de Psychiatrie de Budapest, 1937, 2, 175.Google Scholar
106. Townsend, A. A. D., J. Ment. Sci., 1905, 51, 51.CrossRefGoogle Scholar
107. Tscherkes, L. A., and Mangubi, M. I., Zeit. f. d. ges. Neurol. u. Psychiat., 1931, 132, 815.CrossRefGoogle Scholar
108. Turner, W. J., Dis. Nerv. Syst. (Galveston), 1956, 17, 193, 198.Google Scholar
109. Tverdova, E. B., Zh. Nevropat. psikhiat. Moskva., 1955, 55, 815.Google Scholar
110. Urechia, C. I., et al., Presse Med., 1937, 1784.Google Scholar
111. Wada, J., and Gibson, W. C., A.M.A. Arch. Neurol. and Psychiat. In press.Google Scholar
112. Wahlstrom, G., Acta Psych. and Neurol. 1936–37, 11, 651.Google Scholar
113. Walaas, O., et al., Scand. J. Clin. and Lab. Invest., 1954, 6, 245.CrossRefGoogle Scholar
114. Weber, R., Schweiz. Med. Wochenschr., 1953, 83, 1539; Schweiz. Arch. f. Neurol. u. Psychiat., 1953, 71, 412; Experientia, 1952, 8, 197.Google Scholar
115. Weichbrodt, R., Monatschr. f. Psychiatry, 1922, 51, 364.CrossRefGoogle Scholar
116. Wilczcowski, E., Polski tygodnik lek, 1946, 1, 528.Google Scholar
117. Winter, C. A., and Flataker, L., J. Pharmacol. Exper. Therap., 1951, 101, 156.Google Scholar
118. Idem, Proc. Soc. Exptl. Biol. Med., 1956, 92, 285.CrossRefGoogle Scholar
119. Idem , Report to Soc. Biol. Psychiatry Meeting, Atlantic City, N.J., 1957; A.M.A. Arch. Neurol. and Psychiat., 1958. In press; 3rd Intern. Neurochem. Symposium, 1958, August 25–29.Google Scholar
120. Witt, P. N., Experientia, 1951, 7, 310.CrossRefGoogle Scholar
121. Woolley, D. W., and Shaw, E., Brit. Med. J., 1954, ii, 122.CrossRefGoogle Scholar
122. Kety, S. S., 3rd Intern. Neurochem. Symposium, 1958, 25–29 August.Google Scholar
123. Kielholz, P., Schweiz. Arch. Neurol. u. Psychiat., 1949, 63, 230.Google Scholar
124. Mall, G., Schweiz. Arch. Neurol. u. Psychiat., 1956, 78, 358; 2nd Intern. Congr. on Psychiatry, Zurich, August, 1957.Google Scholar
125. Melander, S., et al., 3rd Intern. Neurochem. Symposium, 1958, 25–29 August.Google Scholar
126. Rieder, H. P., Confinia Neurologica, 1957, 17, 375.CrossRefGoogle Scholar
127. Witt, P., and Weber, R., Monatsch. f. Psych. u. Neurol. 1956, 132, 193.CrossRefGoogle Scholar
128. Freedman, A., and Ginsberg, S., J. Nerv. Ment. Dis., 1958, 126, 294.CrossRefGoogle Scholar
129. Wagner, H., Allgem., Zeits. f. Psychiat., 1942, 119, 124.Google Scholar
130. Buschhaus, O., ibid., 1942, 119, 143.Google Scholar
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