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Phenothiazine Derivatives in the Treatment of Schizophrenia

Published online by Cambridge University Press:  08 February 2018

Lindsay Hurst*
Affiliation:
Shenley Hospital, Hertfordshire

Extract

The use of drugs in order to calm excited mental patients dates back to the 5th Century B.C. or earlier.

The employment of extracts of the mandrake, Mandragora, in states of motor excitement is attributed to Hippocrates (Belloni, 1957). One disadvantage of such extracts was that reduction of agitation and anxiety could only be achieved at a cost of clouding of consciousness. This is also the case with many modern sedatives.

Type
Original Articles
Copyright
Copyright © Royal College of Psychiatrists, 1960 

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References

Abrams, J., Dis. nerv. Syst., 1958, 19, 20.Google Scholar
Achaintre, A., Lambert, P., Beaujard, , Brousolle, P., Berthier, C., Balvet, P., Requet, A., and Revol, L., Pr. méd., 1959, 67, 1095.Google Scholar
Arnold, O. H., Hift, St., and Solms, W., Wien. med. Wschr., 1952, 102, 964.Google Scholar
Azima, H., and Durost, H., Canad. med. Ass. J., 1957, 77, 671.Google Scholar
Baker, A. A., J. ment. Sci., 1955, 101, 175.Google Scholar
Idem and Thorpe, J. G., Arch. Neurol. Psychiat., Chicago, 1957, 78, 57.CrossRefGoogle Scholar
Idem , J. ment. Sci., 1958, 104, 855.Google Scholar
Barrett, W. W., Ellsworth, R. B., Clark, L. D., and Ennis, J., Dis. nerv. Syst., 1957, 18, 209.Google Scholar
Belloni, L., in Psychotropic Drugs, Edited by Garattini, S., and Ghetti, V., 1957, pp. vix. London, Amsterdam, New York, Princeton: Elsevier.Google Scholar
Blair, D., and Brady, D. M., J. ment. Sci., 1958, 104, 625.Google Scholar
Boardman, R. H., Lomas, J., and Markowe, M., Lancet, 1956, ii, 487.CrossRefGoogle Scholar
Borel, , Coiffer, B., and Dechosal, F., Ann. méd.-psychol., 1957, 115(1), 526.Google Scholar
Brooks, G. W., Amer. J. Psychiat., 1959, 115, 931.Google Scholar
Mason-Browne, N. L., ibid., 1957, 114, 173.Google Scholar
Cares, R. M., Asrican, E., Fenichel, M., Sack, P., and Severino, J., ibid., 1957, 114, 318.Google Scholar
Charatan, F. B. E., J. ment. Sci., 1954, 100, 882.CrossRefGoogle Scholar
Cohen, S., Amer. J. Psychiat., 1958, 115, 358.Google Scholar
Darling, H. F., Dis. nerv. Syst., 1958, 19, 428.Google Scholar
Idem , ibid., 1959, 20, 167.Google Scholar
Delay, J., Deniker, P., and Harl, J. M., Ann. méd.-psychol., 1952, 110(2), 112.Google Scholar
Idem , Deniker, P., Ropert, R., Beek, H., Barande, R., and Eurieult, M., Pr. méd., 1959, 67, 123.Google Scholar
Idem , Pichot, P., Lempérière, T., and Elissalde, M. B., Ann. méd.-psychol., 1959, 117(1), 724.Google Scholar
Idem , Pichot, P., and Ropert, R., Pr. méd., 1957, 65, 491.Google Scholar
Denber, H. C. B., and Bird, E. G., Amer. J. Psychiat., 1957, 113, 927.Google Scholar
Idem , Rajotte, P., and Kauffman, D., ibid., 1959, 115, 1116.Google Scholar
Deschamps, A., and Madre, J., Pr. méd., 1957, 65, 1071.Google Scholar
Dransfield, G. A., J. ment. Sci., 1958, 104, 1183.CrossRefGoogle Scholar
Fazekas, J. F., Schultz, J. D., Sullivan, P. D., and Shea, J. G., J. Amer. med. Ass., 1956, 161, 46.Google Scholar
Feldman, P. E., Amer. J. Psychiat., 1957, 114, 237.Google Scholar
Ferguson, J. T., ibid., 1958, 115, 548.Google Scholar
Fleming, B. G., Spencer, A. M., and Whitelaw, E. M., J. ment. Sci., 1959, 105, 349.CrossRefGoogle Scholar
Forrester, M. E., Brit. med. J., 1958, ii, 90.Google Scholar
Fouks, , Lainé, , Ferrant, , and Pagot, , Ann. méd.-psychol., 1959, 117(1), 164.Google Scholar
Freeman, H., Arnold, A. L., and Cline, H. S., Dis. nerv. Syst., 1956, 17, 213.Google Scholar
Gilmore, T. H., and Shatin, L., J. ment. Sci., 1959, 105, 508.CrossRefGoogle Scholar
Goldman, D., Amer. J. med. Sci., 1958, 235, 67.Google Scholar
Gosline, E., Walters, C. J., and Saunders, J. C., Amer. J. Psychiat., 1959, 115, 939.CrossRefGoogle Scholar
Hanlon, T. E., Kurland, A. A., Esquibel, A. J., and Ota, K. Y., J. nerv. ment. Dis., 1958, 127, 17.Google Scholar
Hiob, J., and Hippius, H., Med. Klinik., 1955, 50, 1746.Google Scholar
Hollingworth, H. L., Arch. Psychol., N. Y., 1912, 22, 1.Google Scholar
Kallmann, F. J., The Genetics of Schizophrenia, 1938, pp. 107108. New York: Augustin.Google Scholar
Kehoe, M. J., and Pollard, J. C., J. nerv. ment. Dis., 1956, 123, 275.Google Scholar
King, P. D., Amer. J. Psychiat., 1958, 115, 354.Google Scholar
Idem and Weinberger, W., ibid., 1959, 115, 1026.Google Scholar
Kline, N. S., and Jacob, G. M., ibid., 1955, 112, 63.Google Scholar
Kruse, W., ibid., 1959, 115, 1031.Google Scholar
Kurland, A. A., Arch. Neurol. Psychiat., Chicago, 1956, 75, 510.Google Scholar
Idem and Vasconcellos, J., J. nerv. ment. Dis., 1958, 127, 378.Google Scholar
Little, J. C., J. ment. Sci., 1958, 104, 334.Google Scholar
Malitz, S., and Hoch, P. H., Psychiat. Quart., 1956, 30, 633.Google Scholar
Mathews, F. P., Amer. J. Psychiat., 1958, 114, 1034.Google Scholar
Mead, B. T., Ellsworth, R. B., and Grimmett, J. O., J. nerv. ment. Dis., 1958, 127, 351.Google Scholar
Mitchell, P. H., Sykes, P., and King, A., Brit. med. J., 1957, i, 204.CrossRefGoogle Scholar
Nicoletti, I., and Magherini, G., Rass. Studi psichiat., 1957, 46, 903.Google Scholar
De Nosaquo, N., J. Amer. med. Ass., 1956, 160, 287.Google Scholar
O'Brien, C. F., and Anderson, C. W. G., J. Louisiana med. Soc., 1959, 111, 16.Google Scholar
Perrin, J., Lambert, P.-A., Balvet, P., Brousolle, P., Berthier, C., Beaujard, M., Achaintre, A., Requet, A., and Revol, L., Ann. méd.-psychol., 1958, 116(2), 602.Google Scholar
Rathod, N., and Rees, L., J. ment. Sci., 1958, 104, 705.Google Scholar
Rudy, L. H., Rinaldi, F., Costa, E., Himwich, H. E., Tuteur, W., and Glotzer, J., Amer. J. Psychiat., 1958, 114, 747.CrossRefGoogle Scholar
Sen, G., and Bose, K. C., Indian med. World., 1931, 2, 194.Google Scholar
Shepherd, M., and Watt, D. C., J. Neurol. Psychiat., 1956, 19, 232.Google Scholar
Simpson, R. W., J. ment. Sci., 1958, 104, 179.Google Scholar
Thorpe, J. G., and Baker, A. A., ibid., 1956, 102, 790.Google Scholar
Tuteur, W., Stiller, R., and Whitehill, O., Dis. nerv. Syst., 1957, 18, 100.Google Scholar
Vasconcellos, J., and Kurland, A. A., ibid., 1958, 19, 173.Google Scholar
Vaughan, G. F., Lieberman, D. M., and Cook, L. C., Lancet, 1955, i, 1083.Google Scholar
Walsh, G. P., Walton, D., and Black, D. A., J. ment. Sci., 1959, 105, 199.Google Scholar
Webber, H. A., Personal communication.Google Scholar
Werenberg, H., Nord. med., 1955, 54, 1787.Google Scholar
Wilcox, F., Dis. nerv. Syst., 1958, 19, 118.Google Scholar
Winkelman, N. W. Jr., Amer. J. Psychiat., 1957, 113, 961.Google Scholar
Kinross-Wright, V., Dis. nerv. Syst., 1955, 16, 114.Google Scholar
Idem and Moyer, J. H., Arch. Neurol. Psychiat., Chicago, 1956, 76, 675.Google Scholar
Zoila, A. F., Basset, J., and Lebreton, M., Pr. méd., 1959, 67, 935.Google Scholar
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