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Permeability of the Blood-Brain Barrier to Penicillin in Cases of Parenchymatous Neurosyphilis

Published online by Cambridge University Press:  08 February 2018

Robert H. F. Smith
Robert H. F. Smith*
Affiliation:
Severalls Hospital, Colchester
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Extract

Since the introduction of penicillin into therapeutics the important question of the penetration of the blood-brain barrier by the antibiotic in infections of the nervous system has cropped up. In vital staining experiments Goldman (1913) observed that the acid semi-colloidal dye, trypan blue, which makes its way from the blood into the tissues, is unable to penetrate into the central nervous system. When the dye was injected into the cerebrospinal fluid it passed without difficulty into the brain substance. These observations were later verified by other investigators and have been verified for other substances (dyes, drugs, toxins, etc.).

Type
Part I.—Original Articles
Information
Journal of Mental Science , Volume 97 , Issue 407 , April 1951 , pp. 340 - 361
Copyright
Copyright © Royal College of Psychiatrists, 1951 

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References

Abraham, E. P., Chain, E., Fletcher, C. M., Gardner, A. D., Heatley, N. G., Jennings, M.A., and Florey, H. W. (1941), Lancet, ii, 177.CrossRefGoogle Scholar
Broman, T. (1938), Skand. Arch. Physiol., 80, 59.CrossRefGoogle Scholar
Idem (1940), Arch. Psychiat., 112, 290.CrossRefGoogle Scholar
Idem (1941), Acta. Psych. et Neurol., 16, 1.CrossRefGoogle Scholar
Cairns, H., Duthie, E. S., Lewin, W. S., and Smith, H. V. (1944), Lancet, i, 655.Google Scholar
Callaway, J. L., Lowenbach, H., Noojin, R. O., Kuhn, B. H., and Riley, K. A. (1945). J. Amer. Med. Assoc., 129, 938.CrossRefGoogle Scholar
Cooke, J. V., Goldring, D. (1945), J. Amer. Med. Assoc., 127, 80.CrossRefGoogle Scholar
Dattner, B. (1948), Med. Clin. North Amer., May, p. 707.Google Scholar
Dumoff-Stanley, E., Dowling, H. F., and Sweet, L. K. (1946), J. Clin. Invest., 25, 87.CrossRefGoogle Scholar
Eagle, H., and Musselman, A. D. (1944), J. Exp. Med., 80, 493.Google Scholar
Elkeles, A. (1943), Lancet, i, 764.Google Scholar
Fleming, A. (1943), Ibid., ii, 434.Google Scholar
Idem , Young, M. Y., Suchet, J., and Rowe, A. J. E. (1944). Ibid., ii, 621.Google Scholar
Friedmann, V., and Elkeles, A. (1934), Ibid., i, 719, 755.Google Scholar
Gammon, G. D., Stokes, J. H., Beerman, H., Ingraham, N. R., Lentz, J. W., Morgan, H. G., Steele, W., Rose, E. K., and Mayer, V. (1945). J. Amer. Med. Assoc., 128, 653.Google Scholar
Goldman, E. (1913), Vitalfarbung am Zentralnervensystem. Berlin.Google Scholar
Goldman, D. (1945), J. Amer. Med. Assoc., 128, 274.CrossRefGoogle Scholar
Herrell, W. E. (1944), Ibid., 124, 622.Google Scholar
Idem , Nicholls, D. R., and Heilman, D. H. (1944), Ibid., 125, 1003.Google Scholar
Heyman, A. (1947), Amer. J. Med. Sci., 213, 661.Google Scholar
Kaplan, I., Read, H. S., Becker, F. T., and Seymour, C. F. (1946), J. Lab. and Clin. Med., 31, 317.Google Scholar
Lindsay, J. S. B. (1947), New Zealand Med., J., 254, 308.Google Scholar
Lourie, E. M., Collier, H. O. J., Ross, A. O. F., and Robinson, D. T. (1945), Lancet, ii, 696.Google Scholar
Macklin, C. C., and Macklin, M. T. (1920), Arch. Neurol. Psychiat., 3, 353.CrossRefGoogle Scholar
Moore, J. E. (1944), The Modern Treatment of Syphilis, 2nd ed., p. 370.Google Scholar
McDermott, W., and Nelson, R. A. (1945), Amer. J. Syph., 29, 403.Google Scholar
Nelson, R. A., and Duncan, L. (1945), Ibid., 29, 141.Google Scholar
Neymann, C. A., Heilbrunn, G., and Youmans, G. P. (1945), J. Amer. Med. Assoc., 128, 433.Google Scholar
Purdon, Martin J. (1948), Brit. Med. J., i, 922.Google Scholar
Rammelkamp, C. H., and Keefer, C. S. (1943), J. Clin. Invest., 22, 425.Google Scholar
Randall, W. A., Price, C. W., and Welch, H. (1945). Science, 101, 365.CrossRefGoogle Scholar
Redfearn, J. W. T., Elithorn, A., Till, K., and Ibbott, F. A. (1949). Lancet, ii, 652.Google Scholar
Reid, R. D., and Brewer, J. H. (1946), J. Bact, 52, 2, 251.Google Scholar
Reynolds, F. W., Mohr, C. F., and Moore, J. E. (1946), J. Amer. Med. Assoc., 131, 1255.CrossRefGoogle Scholar
Rose, A. S., and Solomon, H. C. (1947), Ibid., 133, 5.Google Scholar
Rosenberg, D. H., and Sylvester, J. C. (1944), Science, 100, 132.Google Scholar
Schwemlein, G. X., Barton, R. L., Bauer, T. J., Loewe, L., Bundesen, H. N., and Craig, R. M. (1946). J. Amer. Med. Assoc., 130, 340.CrossRefGoogle Scholar
Skoog, T. (1937), Acta Otolaryng. Stockh., 25, 365.CrossRefGoogle Scholar
Smith, H. V., Duthie, E. S., and Cairns, H. (1946), Lancet, i, 185.CrossRefGoogle Scholar
Smith, R. H. F. (1947), Ibid., i, 665.Google Scholar
Idem and de Morais, V. (1948), J. Ment. Sci., 94, 70.Google Scholar
Sorsby, A., Wright, A. D., and Elkeles, A. (1943), Proc. Roy. Soc. Med., 36, 317.Google Scholar
Spatz, H. (1924), Allg. Z. Psychiat., 80, 285.Google Scholar
Idem (1931), Arch. Psychiat., 101, 267.Google Scholar
Stokes, J. H., Sternberg, T. H., Schwartz, W. H., Mahoney, J. F., Moore, J. E., and Wood, W. B. (1944), J. Amer. Med. Assoc., 126, 73.Google Scholar
Idem (1945), Am. J. Syph., Gon. and Ven. Dis., 29, 313.Google Scholar
Ström-Olsen, R., and Kite, E. de C. (1942), J. Ment. Sci., 88, 407.Google Scholar
Thrasher, J. R. (1945), J. Indiana Med. Assoc., 38, 216.Google Scholar
Wallace, G. B., and Brodie, B. B. (1940), J. Pharm. and Exp. Therap., 68, 50, 70, 418.Google Scholar
Worster-Drought, C. (1947), Brit. Med. J., ii, 559.Google Scholar
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