It is exactly forty years ago since Dr. Guye, of Amsterdam, drew the attention of the Section of Otology, at the annual meeting of the British Medical Association held in Leeds in 1889, to the presence of certain mental disabilities, designated aprosexia, which may appear, both after as well as before puberty, in the subjects of chronic nasal disease. I submit that mental symptoms additional to those described by Guye are due to diseased conditions of the nose which produce a persistent catarrh.