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On the Wassermann Reaction in 172 Cases of Mental Disorder (Cardiff City Mental Hospital) and 66 Control Cases, Syphilitic and other (chiefly from Cardiff Infirmary), with Historical Survey for the Years 1906–10, inclusive: Comments and Conclusions.(1)

Published online by Cambridge University Press:  19 February 2018

H. A. Scholberg  and
Edwin Goodall
H. A. Scholberg
Affiliation:
Cardiff Infirmary and the City Mental Hospital
Edwin Goodall
Affiliation:
Cardiff City Mental Hospital
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Extract

The sero-diagnosis of a syphilitic infection, commonly known as the “Wassermann reaction,” is based on the work published by Bordet in 1899, and Bordet and Gengou in 1901. It was there shown that the absence of hæmolysis could be made available as a naked-eye test indicative of a specific infection, and that the occurrence of hæmolysis negatived the existence of such infection. This reaction they showed was due to the fact that the anti-bodies produced by an infection were able to fix complement in the presence of the corresponding antigen, so that an attempt to complete an hæmolytic system after complement had been absorbed was ineffectual, and the homologous red blood-corpuscle remained intact, though exposed to the action of an inactivated homologous hæmolytic serum.

Type
Part I.—Original Articles
Information
Journal of Mental Science , Volume 57 , Issue 237 , April 1911 , pp. 218 - 273
Copyright
Copyright © Royal College of Psychiatrists, 1911 

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