This is the third paper by this author on the same subject. In this case the types of alteration of the nerve-cells were two:—First, the disintegration of the chromatic substance which, reduced to fine granules, was scattered uniformly through the cell, rendering it homogeneous; the nucleus central and unaltered. This is the usual type following toxines. Second, the type with central chromatolysis and deformity, and displacement of the nucleus. This is the type following the cutting of the axis-cylinder process. In this case, this was associated with degeneration of the fibres of various parts of the motor tracts, and was probably an example of the secondary degeneration of the nerve-cell from “reaction at a distance.” The lesion in the pyramidal tracts of the cord stands in relation to the symptoms presented by the patient, e. g. hypertonus, exaggeration of the tendon reflexes, paresis of the upper limbs. The curability of such cases is not in contradiction with the anatomical facts, as the alteration in the nerve-cell is reparable. The primary degeneration of the fibres is probably due to the same toxine as had produced the nerve-cell change.