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Observations on the Short-Acting Relaxant Ro/3/0386

Published online by Cambridge University Press:  08 February 2018

R. B. Taylor
R. B. Taylor*
Affiliation:
Whittingham Hospital, Preston
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Extract

The present investigation covers a series of 110 treatments with electroplexy in which RO/3/0386 has been used as an ultra short-acting relaxant. This is a heteropoly-methylene-bis-trimethylammonium diiodide, Me3N + (CH2)4. S. S. (CH2)4N + Me3. 2I in aqueous solution which, being related to the decamethonium compounds, acts by depolarizing the motor end plate, and results in similar clinical effects to those produced by succinylcholine as described recently by Richards and Youngman (1952), Mayrhofer (1952), Bourne Collier and Somers (1952), and others.

Type
Part I.—Original Articles
Information
Journal of Mental Science , Volume 99 , Issue 414 , January 1953 , pp. 156 - 157
Copyright
Copyright © Royal College of Psychiatrists, 1953 

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References

Bourne, J. G., Collier, H. O. J., and Somers, G. F., Lancet, 1952, i, 1225.Google Scholar
Hurley, M. J., and Monro, A. B., Brit. Med. J., 1952, i, 1027.Google Scholar
Hewer, C. L., ibid., 1952, i, 971.Google Scholar
Mayrhofer, O. K., ibid., 1952, i, 1332.Google Scholar
Richards, H., and Youngman, H. R., ibid., 1952. i, 1334.Google Scholar
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