It is sometimes cast up as a reproach to those engaged in psychiatry that zeal in research, and progress in knowledge in this subject have not kept pace with other departments of medicine, but I now describe some valuable additions to our knowledge which have all been made during the last decade on the diagnostic signs of general paralysis of the insane. Although the full title of this disease is a perpetual reminder of the fact that the credit of its discovery belongs to physicians engaged in asylum practice, it is desirable to drop the final qualification, and refer to it simply as general paralysis.