This is a report of the chemical analysis of iron and calcium in the brains of three cases of Sturge-Weber disease. Although the clinical and pathological features of this syndrome have been well described, the chemistry of the characteristic deposits is less well understood, and there is a conflict of opinion as to whether iron is present in increased amount.

Owing to the kind co-operation of Mr. Alexander of the Neurosurgical Unit, Frenchay Hospital, it has been possible to re-investigate this problem using material derived from lobectomy specimens. The material had been stored in formol saline for some months before the analysis was carried out.

Microscopic examination showed the usual picture of meningeal angioma and massive mineral deposits in the outer part of the affected grey matter. There were also a few concretions lying more deeply in the white matter in all the specimens (Dr. R. M. Norman).