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Iodine-132 Uptakes by the Thyroid in Psychotics

Published online by Cambridge University Press:  08 February 2018

J. L. Crammer  and
W. F. R. Pover
J. L. Crammer
Affiliation:
All Saints' Hospital; and Department of Medical Biochemistry and Pharmacology, University of Birmingham
W. F. R. Pover
Affiliation:
All Saints' Hospital; and Department of Medical Biochemistry and Pharmacology, University of Birmingham
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Extract

The study of thyroid function as the uptake of radioiodine (I131) is a well-established test. Since the half-life of the isotope is long (8 days) it is unreasonable to make frequent repeated tests in the same person because of the cumulative radiation risk and the complexity of interpretation when residual radioactive iodine is still present in the body. However, in psychiatry daily or twice daily measurements of thyroid function might be very useful in studying patients who show sudden or rapid mental changes (Sands, 1958), and a radioiodine isotope with a half-life of only 2·26 hours which has become more readily available (I132), deserves trial. The primary aim of the present work was to make daily measurements on one man through several short (6-day) cycles of behavioural change. He was predominantly manic-depressive in type and has already been described in detail (Crammer, 1959). To discover how variable the measurement could be, repeated observations were also made on a group of 20 chronic male patients living together and showing an unchanging clinical picture. Observations were repeated on them after three months of chlorpromazine treatment to see whether this would have altered the values obtained for thyroid uptake.

Type
Original Articles
Information
Journal of Mental Science , Volume 106 , Issue 445 , October 1960 , pp. 1371 - 1376
Copyright
Copyright © Royal College of Psychiatrists, 1960 

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