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The Fractionation of Urinary Neutral 17-Ketosteroids from Chronic Male Schizophrenics

Published online by Cambridge University Press:  08 February 2018

M. Reiss  and
S. R. Stitch
M. Reiss
Affiliation:
Biochemical and Endocrinological Research Department Bristol Mental Hospitals, Barrow Hospital, Barrow Gurney, near Bristol
S. R. Stitch
Affiliation:
Biochemical and Endocrinological Research Department Bristol Mental Hospitals, Barrow Hospital, Barrow Gurney, near Bristol
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Extract

Investigations carried out in the past into the steroid hormone excretion rate of mental patients have been limited to the quantitative determination of the total compounds. Assay of neutral 17-ketosteroids in particular, has revealed no significant difference in the excretion rates of schizophrenics from that of normal controls (Leth Pedersen, 1947; Lingjaerde and Lierasylet, 1949 et al). Pincus (1943) has studied the diurnal excretion pattern of 17-ketosteroids in normal persons; a different pattern was shown to occur in some schizophrenics (Reiss, Hemphill, Gordon and Cook, 1949). Some schizophrenic patients also show considerably greater fluctuations in the 24-hour excretion rate than normal persons (Reiss et al., 1949), these fluctuations disappearing after successful treatment of the patients (Reiss, 1952). An increased percentage of excreted 3 β-hydroxy-17-ketosteroids has recently been reported (Mittelman, Romanoff, Pincus and Hoagland, 1952) in schizophrenics compared with normal people, the total ketosteroid excretion rate being found similar in both groups. Increased β-ketosteroid excretion rate was also seen by Reiss, Hemphill, Gordon and Cook (1949), during depressive phases in a state of manic depressive psychosis.

Type
Original Articles
Information
Journal of Mental Science , Volume 100 , Issue 420 , July 1954 , pp. 704 - 710
Copyright
Copyright © Royal College of Psychiatrists, 1954 

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