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Experiments on the Prolongation of Induced Epileptiform Convulsions in the Cat

Published online by Cambridge University Press:  08 February 2018

Hugo Ruf
Hugo Ruf*
Affiliation:
From the Department of Neurosurgery, University of Freiburg i. Br., Germany
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Extract

THE present paper offers a brief summary of work which has been published in German journals dealing with the prolongation of induced convulsions. In the course of my experimental research the following phenomena were demonstrated:

  1. (1) Continuousconvulsionslastingup to oneand a half hours were produced by the administration of oxygen and adrenaline, preceded by the injection of phenyl-methyl-aminopropane.

  2. (2) Prolonged convulsions of 33 minutes were produced by the intravenous injection of 2 ml. of a io per cent. metrazol solution and continuous oxygen in suffiation.

  3. (3) Isolated continuous convulsive activity of the cerebellum was produced lasting 30 minutes after cessation of respiration and of all cortical electrical activity. This was achieved by continuous insuffiation of oxygen together with the injection of adrenaline and strychnine.

  4. (4) Activation of a prolonged convulsion up to 11 minutes, without further electric stimulation, was effected via the thalamus by the injection of adrenaline after administration of phenyl-methyl-aminopropane and continuous oxygen in sufflation.

Type
Part I.—Original Articles
Information
Journal of Mental Science , Volume 98 , Issue 412 , July 1952 , pp. 454 - 456
Copyright
Copyright © Royal College of Psychiatrists, 1952 

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References

Jung, R., Arch. f. Psychiat. (German), 1949, 183, 206.Google Scholar
Ruf, H., Nervenarzt, 1950, 21, 109.Google Scholar
Idem, Arch. f. Psychiat. (German), 1951, 187, 97.Google Scholar
Idem, Nervenarzt, 1951, 22, 437.Google Scholar
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