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Clinical Studies with LSD-25 and Two Substances Related to Serotonin
Published online by Cambridge University Press: 08 February 2018
Extract
In 1953, Twarog and Page (1) demonstrated that 5-hydroxytryptamine (serotonin) is present in relatively high concentrations in the brain. At about the same time Gaddum (2) and Woolley and Shaw (3) observed that LSD is a highly potent serotonin antagonist in such tissues as rat uterus and hypothesized that the hallucinogenic effect of LSD might be due to interference in the action of serotonin.
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- Copyright © Royal College of Psychiatrists, 1960
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