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A clinical comparison of phenelzine and electro-convulsive therapy in the treatment of depressive illness

Published online by Cambridge University Press:  08 February 2018

W. J. Stanley  and
H. Fleming
W. J. Stanley
Affiliation:
Winwick Hospital' Warrington, Lancs
H. Fleming
Affiliation:
Winwick Hospital
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Extract

The mono-amine oxidase inhibitors, of which phenelzine (“Nardil”) is one example, were introduced for the treatment of depressive illness as a result of the observation that iproniazid, which is a mono-amine oxidase inhibitor, produced euphoria and increased mental alertness in some tuberculous patients to whom it was given. Trials of iproniazid in mental illness were carried out (Loomer et al., 1957; Cesarman, 1959), but it was found to be very liable to give rise to side-effects, being particularly toxic to the liver. Other less toxic mono-amine oxidase inhibitors such as phenelzine, which is chemically related to iproniazid, were later developed.

Type
Therapeutic Trials
Information
Journal of Mental Science , Volume 108 , Issue 456 , September 1962 , pp. 708 - 710
Copyright
Copyright © Royal College of Psychiatrists, 1962 

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References

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