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A Clinical and Biochemical Study of Monoamine Oxidase Inhibition in Depressed Patients

I. a Clinical Trial of Nialamide

Published online by Cambridge University Press:  08 February 2018

W. G. Dewhurst  and
C. M. B. Pare
W. G. Dewhurst
Affiliation:
Bethlem Royal and The Maudsley Hospitals
C. M. B. Pare
Affiliation:
Bethlem Royal and The Maudsley Hospitals
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Extract

The discovery that iproniazid benefits certain subjects with depression, linked with the demonstration that it inhibits the enzyme monoamine oxidase (MAO), led to the hypothesis that inhibition of MAO was the essential mechanism by which iproniazid caused relief of symptoms (Pletscher, 1959). Iproniazid, unfortunately, can produce serious toxic effects, particularly on the liver (Pare and Sandler, 1959), and this has limited its clinical application. For this reason a search has been made for MAO inhibitors with an effective anti-depressant action yet without the serious toxic effects of iproniazid. Among the newer compounds for which such claims have been made is N-isonicotinoyl (-N-N-benzylcarboxamidoethyl) hydrazine or Nialamide.

Type
Original Articles
Information
Journal of Mental Science , Volume 107 , Issue 447 , March 1961 , pp. 239 - 243
Copyright
Copyright © Royal College of Psychiatrists, 1961 

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References

Pare, C. M. B., and Sandler, M., Lancet, 1959, i, 282.CrossRefGoogle Scholar
Iidem, J. Neurol. Neurosurg. Psychiat., 1959, 22, 247.Google Scholar
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Reitman, S., and Frankel, S., Amer. J. clin. Path., 1957, 28, 56.Google Scholar
“Symposium on the Biochemical and Clinical Aspects of Marsilid and other Monoamine Oxidase Inhibitors”, J. clin. exp. Psychopath., 1958, 19, suppl. 1.Google Scholar
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