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Chlorpromazine and Pecazine in Chronic Schizophrenia

Published online by Cambridge University Press:  08 February 2018

Lindsay Hurst
Lindsay Hurst*
Affiliation:
Shenley Hospital, Hertfordshire
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Extract

In this paper the effect of chlorpromazine is compared with that of pecazinet on the schizophrenic population of three chronic psychiatric wards.

Delay, Deniker and Harl (1952) introduced chlorpromazine into psychiatry. Pecazine was first used by Kline and Jacob (1955) and Hiob and Hippius (1955). Thorpe and Baker (1956), in a double-blind, controlled trial, found that both drugs reduced tension significantly in deteriorated, female, schizophrenic patients. Baker and Thorpe (1957) found that pecazine did not significantly reduce daytime incontinence in deteriorated psychotic patients. The trial was controlled and blind. Jones (unpublished), in a double-blind, controlled trial on disturbed psychotic patients, found chlorpromazine to be effective but could find no evidence that pecazine had any effect.

Type
Original Articles
Information
Journal of Mental Science , Volume 106 , Issue 443 , April 1960 , pp. 726 - 731
Copyright
Copyright © Royal College of Psychiatrists, 1960 

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