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The Bacterial Digestion of Tyrosine, Tryptophane and Histidine in Mental Disease

Published online by Cambridge University Press:  19 February 2018

F. H. Stewart
F. H. Stewart*
Affiliation:
Cheddleton Mental Hospital, near Leek
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Extract

It has often been suggested that functional diseases of the nervous system are caused by intestinal toxæmia, and this suggestion has been revived by certain recent work.

Buscaino (1923–26)has described lesions of the small intestine in mental patients which result in undue permeability of its walls. He also describes a toxic substance in the urine in acute confusional and alcoholic insanity and in dementia præcox. This substance is brought down as a black precipitate by silver nitrate in the cold. The liver is deranged in these cases, and decarboxylates amino-acids presented to it instead of deaminizing them.

Type
Part I.—Original Articles
Information
Journal of Mental Science , Volume 75 , Issue 308 , January 1929 , pp. 53 - 63
Copyright
Copyright © Royal College of Psychiatrists, 1929 

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References

Buscaino, V. M., 1923, Riv. di Patologia nervosa e mentale, xxiii, p. 355; ibid., xxiii, p. 437; 1925, ibid., xxx, p. 216; 1926, Studi Neurologici dedicati a Eugenio Tanzi.—Dale and Laidlaw, 1910, Journ. Physiol., xli, p. 318.Google Scholar
Ewins, and Laidlaw, , 1910, ibid., xli, p. 78; 1911, Biochem. Journ., vi, p. 141; 1913, ibid., vii, p. 18.Google Scholar
Koessler, and Hanke, , 1919, 1922, 1924, Journ. Biol. Chem., a series of twenty-one paperes.Google Scholar
Mellanby, and Twort, , 1912, Journ. Physiol., xlv, p. 53.Google Scholar
Scheiner, E., 1927, Riv. di Pat. nervosa e mentale, xxxii, p. 544; 1928, ibid., xxxii, p. 298.Google Scholar
Stewart, F. H., 1928, Journ. Ment. Sci., lxxiv, p. 416.Google Scholar
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