Hostname: page-component-586b7cd67f-gb8f7 Total loading time: 0 Render date: 2024-11-22T13:06:53.080Z Has data issue: false hasContentIssue false
  • English
  • Français

Alzheimer's Disease Confirmed by Cerebral Biopsy: a Therapeutic Trial with Cortisone and A.C.T.H.

Published online by Cambridge University Press:  08 February 2018

M. Sim  and
W. Thomas Smith
M. Sim
Affiliation:
United Birmingham Hospitals
W. Thomas Smith
Affiliation:
University of Birmingham
Get access Rights & Permissions [Opens in a new window]

Extract

This paper describes treatment with cortisone and A.C.T.H. of two patients in whom Alzheimer's Disease (A.D.) had been confirmed histologically by cerebral biopsy.

A.D. is a progressive dementia which usually occurs between the ages of 40 and 60 years, and there is no known specific treatment. Intellectual deterioration, which progresses insidiously over a period of 2–10 years, leads to gross dementia, and the inevitable problems of care and supervision often necessitate removal to an institution. Histologically the disease is characterized by atrophy of cortical nerve cells and the presence within the cortex of argentophile plaques which are demonstrable by the silver impregnation techniques of Bielschowsky or von Braunmühl (see Fig. 1); these plaques have a mixed granular and fibrillary structure. The same silver methods also show irregular thickening and disorientation of the nerve cell fibrils, which form “tangles” and “loops” (see Fig. 2). Identical plaques and neurofibrillary changes are also seen in senile dementia, the term “senile plaque” being used in both diseases.

Type
Original Articles
Information
Journal of Mental Science , Volume 101 , Issue 424 , July 1955 , pp. 604 - 609
Copyright
Copyright © Royal College of Psychiatrists, 1955 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Critchley, M., J. Neurol. Psychopath., 1929, 10, 124.CrossRefGoogle Scholar
Delay, J., Neveu, P., and Deschaux, P., Rev. Neurolog., 1944, 76, 263.Google Scholar
Dixon, K. C., and Herbertson, B. N., J. Path. Bact., 1950, 62, 335.CrossRefGoogle Scholar
Idem , Ibid., 1951,63, 175.Google Scholar
Dixon, K. C., Ibid., 1953a, 66, 251.Google Scholar
Idem , Ibid., 1953b, 66, 539.Google Scholar
Divry, P., Journal Belge de Neurol. et de Psych., 1927, 27, 643.Google Scholar
Goodman, L., J. Nerv. and Ment. Dis., 1953, 117, 97.CrossRefGoogle Scholar
Green, M. A., Stevenson, L. D., Fonseca, J. E., and Wortis, S. B., Dis. Nerv. Syst., 1952, 13, 303.Google Scholar
Hiroisi, S., and Lee, C. C., Arch. Neurol. Psychiat., Chicago, 1936, 35, 827.CrossRefGoogle Scholar
McMenemey, W. H., J. Neurol. Psychiat., 1940, 3, 211.CrossRefGoogle Scholar
Idem , Ibid., 1941, 4, 48.Google Scholar
Neumann, M. A., and Cohn, R., Arch. Neurol. Psych., 1953, 69, 615.Google Scholar
Newton, R. D., J. Ment. Sci., 1948, 94, 225.CrossRefGoogle Scholar
Peräsalo, O., and Latvalahti, J., Acta. path. microbiol., Scand., 1954, 34, 208.CrossRefGoogle Scholar
Polatin, P., Hoch, P. H., Horwitz, W. A., and Roizin, L., Amer. J. Psychiat., 1948, 105, 96.CrossRefGoogle Scholar
Sjögren, T., Sjögren, H., and Lindgren, A. G. H., Morbus Alzheimer and Morbus Pick, 1952. Copenhagen: Ejnar Munksgaard.Google ScholarPubMed
Stengel, E., J. Ment. Sci., 1943, 89, 1.CrossRefGoogle Scholar
Teilum, G., Annals Rheum. Dis., 1952, 11, 119.CrossRefGoogle Scholar
Submit a response

eLetters

No eLetters have been published for this article.