So much has been written on this subject, that I trust it will not be considered disrespectful to previous observers if I refer more particularly to my own experience and observations. As out-patient physician to Charing Cross Hospital, and latterly physician in charge of wards, I have had a considerable experience in seeing the effects of alcohol in the production of bodily diseases; but as Pathologist to the London County Asylums I have had a much larger experience in seeing the effects of alcohol in the production of mental diseases. I can safely say that in quite one fourth of the male cases which come under my observation at Charing Cross Hospital, and in a considerable proportion of the female cases, alcohol has been an efficient cause in the disease, or a very important coefficient. In conjunction with venereal disease, especially syphilis, it is responsible for many degenerative processes, which will be alluded to. My house-physician, Mr. Reade has kindly made a tabulated statement referring to the influence of alcohol in the medical cases admitted during the year 1905, which is appended.