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Toward an Integrated Theory of Schizophrenia

Published online by Cambridge University Press:  08 February 2018

Emil G. Conason  and
Percy E. Ryberg
Emil G. Conason
Affiliation:
New York, N. Y.
Percy E. Ryberg
Affiliation:
Falkirk Hospital, Central Valley, New York
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Extract

Evidence is accumulating that schizophrenia is a disease involving “immunoallergic” sensitization of the tissues of the central nervous system. Variations in its symptomatology may in part depend upon the altered ability of the sensitized nervous tissue to bind or release serotonin, and perhaps other endogenous catechol amines. Accumulation of these products; their rates of turnover; the presence of endogenous enzyme enhancers or inhibitors; specific endocrine dyscrasias; blood-brain barrier conditioners; as well as cellular changes in electrolytes, may all play a part in the process. Genetic defects; lags in maturation; autonomic imbalance and pre-psychotic personality structure may lurk in the background.

Type
Original Articles
Information
Journal of Mental Science , Volume 104 , Issue 435 , April 1958 , pp. 372 - 376
Copyright
Copyright © Royal College of Psychiatrists, 1958 

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