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A Study of the Use of Azacyclonal Hydrochloride (“Frenquel”) in Chronic Schizophrenia

Published online by Cambridge University Press:  08 February 2018

C. F. Lascelles  and
L. J. Levene
C. F. Lascelles
Affiliation:
Cherry Knowle Hospital, Ryhope, near Sunderland
L. J. Levene
Affiliation:
Cherry Knowle Hospital, Ryhope, near Sunderland
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Extract

In February, 1955, Howard D. Fabing described in Science (Fabing, 1955a) a clinical study using the drug azacyclonal hydrochloride (Frenquel), alpha-(4-piperidyl) benzhydrol hydrochloride. This drug is the gamma-isomer of Meratran which, although chemically similar, alpha-(2-piperidyl) benzhydrol hydrochlroide, has a rather different action. Brown and Werner (unpublished but referred to by Fabing, 1955a) reported that Frenquel prevents or diminishes central stimulation induced in the mouse by various agents, whereas Meratran has a stimulant action.

Type
Original Articles
Information
Journal of Mental Science , Volume 105 , Issue 438 , January 1959 , pp. 247 - 250
Copyright
Copyright © Royal College of Psychiatrists, 1959 

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References

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