Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-09T06:39:59.948Z Has data issue: false hasContentIssue false
  • English
  • Français

Some Problems of Pathogenesis in Schilder's Disease

(With Description Of A New Familial Case.)

Published online by Cambridge University Press:  19 February 2018

Alfred Meyer  and
Francis Pilkington
Alfred Meyer
Affiliation:
Central Pathological Laboratory of the L.C.C. Mental Hospitals and the Maudsley Hospital
Francis Pilkington
Affiliation:
Central Pathological Laboratory of the L.C.C. Mental Hospitals and the Maudsley Hospital
Get access Rights & Permissions [Opens in a new window]

Extract

Since we do not yet know the real nature of Schilder's disease nor see a direct way of investigating it, research on this problem can usefully be carried out in two ways: (1) careful description of cases in all possible clinical and pathological detail, and (2) broad comparative studies. That collection of further case-material is still useful was shown, we hope, in the description of a family by one of us (A. M.) in collaboration with Tennent (24). In this family there was a pronounced tendency to gastro-intestinal troubles preceding the nervous symptoms, and the same has been reported by Globus and Strauss (15), Globus (14), and F. Bielschowsky (2). Too much importance must not be attached to such findings, as the onset of the disease just as often follows measles, influenza and other acute infectious conditions; and there is the striking familial taint of tuberculosis in the families described by Symonds (45) and van Bogaert and Scholz (47), and atrophy of the suprarenals was associated with the disease in the latest case reported by R. Pfister (29). The great variety of such preceding illnesses makes us rather chary of regarding them as of direct ætiological or pathogenic significance. It is, on the other hand, of the greatest importance to keep such occurrences carefully in mind, because we do not know yet what common pathogenic factor may lie hidden behind these various initial symptoms. As regards gastro-intestinal troubles, their significance in various avitaminous and other deficiency conditions is generally known, and they have been a very obvious initial symptom in the demyelinizing disease of monkeys, the histopathological kinship of which to Schilder's disease has already been shown in A. Meyer and Tennent's paper, and which will be discussed later in this contribution. This kinship appears to us to be closer than was recognized by Schob (35), Spielmeyer (42), Scherer (33), and Davison (9).

Type
Part I.—Introduction
Information
Journal of Mental Science , Volume 82 , Issue 341 , November 1936 , pp. 812 - 826
Copyright
Copyright © Royal College of Psychiatrists, 1936 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

(1) Benoit, W., Zeitschr. f. d. ges. Neur. u. Psychiat., 1932, cxl, p. 517.CrossRefGoogle Scholar
(2) Bielschowsky, F., Journ. f. Psych. u. Neur., 1927, xxxiii, p. 12.Google Scholar
(3) Bielschowsky, M., and Henneberg, R., Journ. f. Psych. u. Neur., 1928, xxxvi, p. 131.Google Scholar
(4) Idem and Maas, O., ibid., 1932, xliv, p. 138.Google Scholar
(5) Bodechtel, F., Zeitschr. f. d. ges. Neur. u. Psychiat., 1929, cxxi, p. 487.CrossRefGoogle Scholar
(6) Bodechtel, G., and Guttmann, E., ibid., 1932, cxxxviii, p. 544.Google Scholar
(7) Bouman, L., Diffuse Sclerosis, Bristol, 1934.Google Scholar
(8) Cobb, Stanley, in Penfield, , Cytology and Cellular Pathology of the Central Nervous System, New York, 1932, p. 575.Google Scholar
(9) Davison, Charles, Journ. Neur. and Psychopath., 1934, xiv, p. 227.CrossRefGoogle Scholar
(10) Ferraro, , Psych. Quarterly, 1933, vii, p. 267.Google Scholar
(11) Idem, Arch. Neur. and Psychiat., 1928, xx, p. 1065.Google Scholar
(12) Ford, Crothers and Putnam, , Birth Injuries of the Central Nervous System, Baltimore, 1927.Google Scholar
(13) Gans, , Nederl. Tijds. v. Geneesk., 1923, lxvii, p. 1043.Google Scholar
(14) Globus, I. H., in Penfield, , Cytology and Cellular Pathology of the Central Nervous System, New York, 1932, iii, p. 1145.Google Scholar
(15) Globus, I. H., and Strauss, I., Arch. Neur. and Psychiat., 1928, xx, p. 1190.Google Scholar
(16) Gozzano, and Vizzioli, , Rev. Neur., 1932, v, p. 257.Google Scholar
(17) Grinker, Roy R., Zeitschr. f. d. ges. Neur. u. Psychiat., 1925, xcviii, p. 433.CrossRefGoogle Scholar
(18) Guttmann, E., Zentralbl. f. d. ges. Neur. u. Psychiat., 1925, xli, p. 1.Google Scholar
(19) Hallervorden, I., and Spatz, H., Arch. f. Psychiat., 1933, xcviii, p. 641.CrossRefGoogle Scholar
(20) Innes, I. R. M., Proc. Roy. Soc. Med., 1936, xxix, p. 406.CrossRefGoogle Scholar
(21) Jaburek, , Arch. f. Psychiat., 1936, cv, p. 120.Google Scholar
(22) Kufs, H., ibid., 1931, xciii, p. 564.Google Scholar
(23) Liebers, M., Zeitschr. f. d. ges. Neur. u. Psychiat., 1928, cxv, p. 487.Google Scholar
(24) Meyer, A., and Tennent, T., Brain, 1936, lix, p. 100.Google Scholar
(25) Meyer, A., Zeitschr. f. d. ges. Neur. u. Psychiat., 1927, cxii, pp. 172 and 187.Google Scholar
(26) Neuburger, K., ibid., 1922, lxxvi, p. 384.Google Scholar
(27) Patrassi, G., Virchow's Arch., 1931, cclxxxi, p. 98.Google Scholar
(28) Pette, H., Verh. ges. Deutsche Nerven., Berlin, 1930, p. 17.Google Scholar
(29) Pfister, R., Arch. f. Psychiat., 1936, cv, p. 1.Google Scholar
(30) Putnam, T. J., Arch. Neur. and Psychiat., 1935, xxxiii, p. 929.Google Scholar
(31) Idem, ibid., 1936, xxxv, p. 1289.Google Scholar
(32) Rydberg, E., Acta pathol. et microsc. Scand. Suppl., 1932, p. 10.Google Scholar
(33) Scherer, H. I., Zeitschr. f. d. ges. Neur. u. Psychiat., 1932, cxli, p. 212.Google Scholar
(34) Schilder, P., ibid., 1912, x, p. 1.Google Scholar
(35) Schob, F., ibid., 1931, cxxxv, p. 95.Google Scholar
(36) Idem , Bumke's Handbuch d Geisterkr., 1930, xi, p. 981.Google Scholar
(37) Scholz, W., Zeitschr. f. d. ges. Neur. u. Psychiat., 1925, xcix, p. 651.Google Scholar
(38) Schwartz, P., Ergebn. d. inneren Med. u. Kinderh., 1927, xxxi, p. 165.Google Scholar
(39) Idem, Zeitschr. f. d. ges. Neur. u. Psychiat., 1924, xc, p. 263.Google Scholar
(40) Schwartz, and Fink, , Zeitschr. f. Kinderheilk., 1926, xl, p. 427.Google Scholar
(41) Spatz, H., Bumke's Handbuch der Geisterkr., 1930, xi, p. 157.Google Scholar
(42) Spielmeyer, W., Zeitschr. f. Hyg. u. Infektionskr., 1931, cxiii, p. 170.Google Scholar
(43) Steiner, G., Zentralbl. f. d. ges. Neur. u. Psychiat., 1933, lxviii, p. 289.Google Scholar
(44) Stewart, P., Greenfield, J. G., and Blandy, , Brain, 1927, 1, p. 1.Google Scholar
(45) Symonds, , ibid., 1927, 1, p. 256.Google Scholar
(46) Van Bogaert, L., and Nissen, René, Rev. Neur., 1936, lxv, p. 21.Google Scholar
(47) Van Bogaert, L., and Scholz, W., Zeitschr. f. d. ges. Neur. u. Psychiat., 1932, cxli, p. 510.CrossRefGoogle Scholar
(48) Waggoner, and Löwenberg, , Arch. f. Psychiat., 1935, ci, p. 184.Google Scholar
(49) Walthard, K., Zeitschr. f. d. ges. Neur. u. Psychiat., 1930, cxxiv, p. 176.CrossRefGoogle Scholar
(50) Wertham, F., Arch, of Neur. and Psychiat., 1932, xxvii, p. 1380.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.