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The Significance of Brain Acetylcholine

Published online by Cambridge University Press:  08 February 2018

J. Crossland*
Affiliation:
From the Neuropsychiatric Research Centre,† Whitchurch Hospital, Cardiff

Extract

Until a few years ago there existed a sharp dichotomy of opinion between the pharmacologists, who, on the basis of their experiments, assigned to acetylcholine the role of universal synaptic transmitter, and the electrophysiologists, who denied that this substance could effect the transfer of excitation from one conducting element to another. It is, however, now generally agreed that, certainly at the neuromuscular junction, and probably also at ganglionic and some—but not all—central synapses, acetylcholine does indeed exert a primary transmitter action. It must be added that recognition of this fundamental action has been hastened as a result of recent experiments by those very electrophysiologists (such as Eccles and his colleagues) who previously supported exclusively electrical hypotheses of nervous transmission. For this reason the assumption which is implicit throughout this paper that the acetylcholine in brain is concerned in maintaining central synaptic transmission is likely to go unchallenged and requires no detailed justification here.

Type
Part I.—Original Articles
Copyright
Copyright © Royal College of Psychiatrists, 1953 

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References

Elliott, K. A. C., Swank, R. L., and Henderson, Nora, Amer. J. Physiol., 1950, 162, 469.Google Scholar
Feldberg, W. Physiol. Rev., 1945, 25, 596.CrossRefGoogle Scholar
Goodwin, J. E., Kerr, W. K., and Lawson, F. L., Amer. J. Psychiat., 1940, 96, 1389.Google Scholar
Richter, D., and Crossland, J., Amer. J. Physiol., 1949, 159, 247.Google Scholar
Rosenblueth, A., Lissak, K., and Lanari, A., ibid., 1939, 128, 31.Google Scholar
Tobias, J. M., Lipton, M. A., and Lepinat, A. A., Proc. Soc. exp. Biol. N.Y., 1946, 61, 51.Google Scholar
Toman, J. E. P., Swinyard, E. A., and Goodman, L. S., J. Neurophysiol., 1946, 90, 231.Google Scholar
Torda, Clara, and Wolff, H. G., Amer. J. Physiol., 1947, 151, 345.CrossRefGoogle Scholar
Tower, D. B., and McEachern, D., Can. J. Res., 1949, 27, 120.Google Scholar
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