Within the last two or three years a considerable amount of work has been done in this country in the treatment of general paralysis by malarial inoculation. While it is yet too soon to form a final opinion on the results of the experiment, the present seems to be an opportune moment for reviewing what has been done, and for reaching at least some tentative conclusions. In this connection it is important to remember that the method is not altogether new, as it has been in use on the continent for the last seven years with but short interludes.