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Prochlorperazine (Stemetil) in Mental Deficiency

Published online by Cambridge University Press:  08 February 2018

T. L. Pilkington
T. L. Pilkington*
Affiliation:
Glenfrith Hospital, Leicester
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Extract

The use of tranquillizers in mental deficiency has shown a divergency of effects. Noce, Williams and Rapaport (1) claimed that reserpine produced some improvement in all their thirteen adult hyperactive low-grades, and Rettig (2) reported that chlorpromazine produced decreased hyperactivity in twenty-three of his twenty-seven adult defectives of all grades. Blair and Herold (3), using ten “matched-pairs” of hyperactive defective children, found behaviour improvements in nine of them on chlorpromazine, with an average I.Q. gain of 10.4. Using six different tranquillizers on twenty-five adult defectives of all grades, Rudy, Himwich and Rinaldi (4), found that all gave some benefit, with chlorpromazine the most effective. Fischer (5) showed that twenty out of his twenty-two low-grade adult defectives (many with psychotic overlay) were improved in behaviour on reserpine. Using sixteen “matched-pairs” of E.S.N. children, Segal and Tansley (6) claimed that hydroxyzine produced improved scholastic performance in fourteen of them, and Bergin and Bergin (7) stated that the epileptics in particular in their thirty-four low-grades were improved by promazine hydrochloride.

Type
Original Articles
Information
Journal of Mental Science , Volume 105 , Issue 438 , January 1959 , pp. 215 - 219
Copyright
Copyright © Royal College of Psychiatrists, 1959 

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References

1. Noce, R. H., Williams, D. B., and Rapaport, W., “Reserpine (Serpasil) in the Management of the Mentally Ill and Mentally Retarded”, J. Amer. Med. Ass., 1954, 156, 9.CrossRefGoogle Scholar
2. Rettig, J. H., “Chlorpromazine for the Control of Psychomotor Excitement in the Mentally Deficient”, J. Nerv. and Ment. Dis., 1955, 122, 2.CrossRefGoogle Scholar
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4. Rudy, L. H., Himwich, H. E., and Rinaldi, F., “A Clinical Evaluation of Psycho-pharmacological Agents in the Management of Disturbed Mentally Defective Patients”, Amer. J. Ment. Def., 1958, 62, 5.Google Scholar
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6. Segal, L., and Tansley, A. E., “A Clinical Trial of Hydroxyzine (‘Atarax’) on a Group of Maladjusted E.S.N. Children”, ibid., 1957, 103, 432.Google Scholar
7. Bergin, J. T. F., and Bergin, Mary M., “The Use of Sparine in Low-Grade Mental Defectives”, J. Irish. Med. Ass., 1958, 52, 247.Google Scholar
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9. Craft, M., “Tranquillisers in Mental Deficiency: Hydroxyzine”, ibid., 1957, 103, 433.Google Scholar
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11. Milne, H. B., and Berliner, F., “A Clinical Trial of Stemetil”, J. Ment. Sci., 1958, 104, 436.Google Scholar
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