There is certainly no physician now engaged in the treatment of mental disease, who is not perfectly acquainted with that peculiar form of malady designated as general paralysis. In the wards of the public hospitals for the insane, in our consulting rooms, and in our private asylums, the disease in all its stages is perpetually passing under our observation. Its claim to rank as a special form of disorder is perfectly understood; its diagnosis has become speedy and certain; and yet in general medicine it is almost unknown, its most prominent features are overlooked; its indices are disregarded, and its very existence, except as either a modification of paralysis or a complication of lunacy, has been and is denied by able and experienced practitioners.