IN Wright's earliest researches on the opsonic body in human blood serum he used various strains of staphylococci. He found in various forms of staphylococcal invasion, such as acne, furunculosis, and sycosis, that the index of the patient so infected was lower than that of an ordinary healthy individual to the particular organism causing the disease. By his method of inoculation of a vaccine made from the infecting organisms he was able to greatly improve the condition and even cure most intractable cases. Bullock has obtained like results, and cases have been recorded where pneumococcal and other infective diseases have been cured by similar treatment.