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Millon's Reaction in the Urine of Mentally Defective Patients

Published online by Cambridge University Press:  08 February 2018

Caecilia E. M. Pugh
Caecilia E. M. Pugh*
Affiliation:
From the Research Department, Royal Eastern Counties Institution, Colchester
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Extract

Unhydrolysed urine does not usually give a strong Millon's reaction in healthy people, but various workers have reported a strongly positive Millon's reaction in the unhydrolysed urine of mentally defective patients. Schemer (1927, 1928) worked up such urines for tyrosine with negative result, and also showed that the reaction was not due to free phenol or oxy-acid. He claimed (1929) to have isolated the substance responsible, but did not identify it. Lieb and Schadendorff (1929) showed that the substance isolated was impure sodium acetate formed in the method of isolation. The mystery of the substance giving the Milon's reaction was thus left unsolved.

Type
Research Article
Information
Journal of Mental Science , Volume 86 , Issue 361 , March 1940 , pp. 244 - 247
Copyright
Copyright © Royal College of Psychiatrists, 1940 

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References

Blazso, S. (1937), Magyar Orvosi Arch., 38, 378.Google Scholar
Gullotta, S. (1929), Boll. soc. Ital. biol. sper., 4, 803.Google Scholar
Lieb, H., and Schadendorff, E. (1929), Z. physiol. Chem., 184, 108.CrossRefGoogle Scholar
Scheiner, E. (1927), Riv. di Pat. nervosa e mentale, 32, 544.Google Scholar
Idem (1928), Ibid., 32, 298.Google Scholar
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Stewart, F. H. (1929), Journ. Ment. Sci., 75, 53.CrossRefGoogle Scholar
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