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The Meinicke Klarungs Reaction: The Development of an Improved Test

Published online by Cambridge University Press:  08 February 2018

W. M. Ford Robertson
Affiliation:
West of Scotland Neuro-Psychiatric Research Institute, Glasgow
D. B. Colquhoun
Affiliation:
West of Scotland Neuro-Psychiatric Research Institute, Glasgow

Extract

The stimulus behind this investigation was created by various factors which can only be enumerated briefly. In the course of routine sero-diagnosis of syphilis in psychiatric work at the Institute during the last five years, it became evident that, of the three flocculation tests employed, the Kahn (Kahn, R. L., 1928), Müller-Ballungs reaction (Müller, R., 1929), and Meinicke Klarungs reaction (Meinicke, E., 1929), the Meinicke original extract gave results superior in sensitivity. This feature was shown particularly in very early infections and treated cases. Three Wassermann tests, the standard method for psychiatry (Mann, S. A., and Partner, F., 1931), the Wyler drop technique (Wyler, E. J., 1929), and the Browning and Kennaway methods (Browning, C. H., and Kennaway, 1924), run concurrently, could not claim to be as good in this respect, and further, were liable to give non-specific results. The explanation of some of the anomalous reactions of one or another of the three hæmolytic systems seems to lie chiefly in the fact that sera from psychotic and mentally defective patients contain in larger degree elements that are prone to disturb specificity.

Type
Part I.—Original Articles
Copyright
Copyright © Royal College of Psychiatrists, 1939 

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References

References.

Browning, C. H., and Kennawav, .—Recent Methods in the Diagnosis and Treatment of Syphilis, second edition, 1924.Google Scholar
Kahn, R. L.The Kahn Test, 1928.Google Scholar
Mann, S. A., and Partner, F.Memorandum on the Wassermann Reaction in Mental Hospital Practice, first edition, 1931.Google Scholar
Meinicke, E.Münch. med. Wochenschr., 1929, lxxvi, pp. 318, 628, 1965.Google Scholar
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Idem .—Ibid., January, 1933.Google Scholar
Wyler, E. J.H.M.S. Special Report Series, No. 129, 1929.Google Scholar
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