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Investigations into Glutamic Acid Metabolism in Schizophrenics

Published online by Cambridge University Press:  08 February 2018

Poul Astrup ,
Henning G⊘tzsche ,
Bj⊘rn Ibsen And  and
Ib Munkvad
Poul Astrup
Affiliation:
From the Psychiatric Department (Senior Physician: Villars Lunn) and the Medical Department B (Senior Physician: Erik Warburg) of Rigshospitalet, University of Copenhagen, Denmark, and from the Central Laboratory of the Blegdam Hospital (Director: Poul Astrup), Copenhagen, Denmark
Henning G⊘tzsche
Affiliation:
From the Psychiatric Department (Senior Physician: Villars Lunn) and the Medical Department B (Senior Physician: Erik Warburg) of Rigshospitalet, University of Copenhagen, Denmark, and from the Central Laboratory of the Blegdam Hospital (Director: Poul Astrup), Copenhagen, Denmark
Bj⊘rn Ibsen And
Affiliation:
From the Psychiatric Department (Senior Physician: Villars Lunn) and the Medical Department B (Senior Physician: Erik Warburg) of Rigshospitalet, University of Copenhagen, Denmark, and from the Central Laboratory of the Blegdam Hospital (Director: Poul Astrup), Copenhagen, Denmark
Ib Munkvad
Affiliation:
From the Psychiatric Department (Senior Physician: Villars Lunn) and the Medical Department B (Senior Physician: Erik Warburg) of Rigshospitalet, University of Copenhagen, Denmark, and from the Central Laboratory of the Blegdam Hospital (Director: Poul Astrup), Copenhagen, Denmark
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Extract

Earlier investigations (3, 4) have shown an abnormal glutamic acid metabolism in schizophrenic patients.

These changes are, briefly, low glutamic acid level (and high glutamine level) especially in acute cases. Glutamic acid concentrations below 1.2 milli grams per 100 ml. venous blood were ascertained in most of these patients.

Type
Original Articles
Information
Journal of Mental Science , Volume 101 , Issue 423 , April 1955 , pp. 366 - 369
Copyright
Copyright © Royal College of Psychiatrists, 1955 

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References

1. Astrup, P., and Munkvad, I., “On the determination of glutamine and glutamic acid in plasma”, Scand. Jour. Clin. and Lab. Invest., 1950, 2, 133.Google Scholar
2. Krebs, H. A., “Quantitative determination of glutamine and glutamic acid”, Biochem. J., 1948, 43, 51.CrossRefGoogle Scholar
3. Munkvad, I., “Glutaminsyre og glutaminbestemmelser i plasma paa et psykiatrisk patientmateriale”, Thesis, 1951, Copenhagen.Google Scholar
4. Idem , “Determinations of glutamine and glutamic acid in a material of mental patients”, Preliminary report. Acta psych. et neurol., 1950, 25, 269.Google Scholar
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