Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-03T00:59:08.988Z Has data issue: false hasContentIssue false
  • English
  • Français

Indoluria in Schizophrenia:

I. Statistical Study and Investigation of Hepatic Function

Published online by Cambridge University Press:  08 February 2018

A. D. Forrest
A. D. Forrest*
Affiliation:
University of Edinburgh
Get access Rights & Permissions [Opens in a new window]

Extract

Investigation of the urinary excretion of indoles in psychotic illnesses has a certain historical precedent. Thus Townsend (1905) and Bruce (1906) reported excess of indican in the urine of melancholic patients. Bruce correlated this finding with the recognized tendency to constipation in depressives and treated his patients with enemata. Ross (1913) reported that schizophrenic subjects excreted an excess of indole-acetic acid in the urine. De Jong (1945) reported the experimental induction of catalepsy in cats by the intravenous administration of indolethylamine and noted in his monograph that this substance, if perfused in vitro through the liver, is converted to indole-acetic acid. Buscaino (1952) reported finding abnormal amounts of primary and secondary amines in the urine of schizophrenics. More recently Riegelhaupt (1956, 1958) has reported an excess of tryptophan metabolites in schizophrenic urine while McGeer and co-workers (1957) have reported a difference in the excretion of aromatic substances as between normals and schizophrenics. Though these authors do not make the point clear, yet in fact indoles come under the general heading of aromatic substances.

Type
Original Articles
Information
Journal of Mental Science , Volume 105 , Issue 440 , July 1959 , pp. 674 - 684
Copyright
Copyright © Royal College of Psychiatrists, 1959 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Bloch, R. J., Durrum, E. L., and Zweig, G., Paper Chromatography and Paper Electrophoresis, 1958. New York, p. 82.Google Scholar
2. Brodie, B. B., Pletscher, A., and Shore, P. A., Science, 1955, 122, 968.CrossRefGoogle Scholar
3. Idem , Shore, P. A., and Pletscher, A., ibid., 1956, 123, 992.Google Scholar
4. Bruce, L. C., J. Ment. Sci., 1906, 52, 501.CrossRefGoogle Scholar
5. Buscaino, V. M., in Proc. 1st Internat. Congress Neuropath., 1952. Rome, p. 545.Google Scholar
6. Buscaino, G. A., and Stefanachi, L., A.M.A. Arch. Neurol. Psychiat., 1958, 80, 78.CrossRefGoogle Scholar
7. Dawson, A. M., McLaren, J., and Sherlock, S., Lancet, 1957, ii, 1263.CrossRefGoogle Scholar
8. De Jong, H., Experimental Catatonia, 1945. Baltimore.Google Scholar
9. Easterbrook, C. C., J. Ment. Sci., 1906, 52, 766.CrossRefGoogle Scholar
10. Forrest, A. D., ibid., 1957, 103, 614.Google Scholar
11. Greville, G. D., Proc. Roy. Soc. Med., 1945, 38, 671.Google Scholar
12. Hanger, F. M., J. Clin. Invest., 1939, 18, 261.CrossRefGoogle Scholar
13. Heath, R. G., Martens, S., Leach, B. E., Cohen, M., and Feighley, C. A., Amer. J. Psychiat., 1958, 114, 917.CrossRefGoogle Scholar
14. Hoffer, A., J. Clin. Exp. Psychopath., 1957a, 18, 27.Google Scholar
15. Idem , in Hormones, Brain Function and Behaviour (Ed.: Hoagland, H.), 1957b. New York.Google Scholar
16. Idem , Osmond, H., and Smythies, J., J. Ment. Sci., 1954, 100, 29.Google Scholar
17. Horwitt, M. K., Science, 1956, 124, 429.CrossRefGoogle Scholar
18. Jepson, J. B., Lancet, 1955, ii, 1009.CrossRefGoogle Scholar
19. Knox, E., and Meyler, A. H., J. Biol. Chem., 1950, 187, 419.CrossRefGoogle Scholar
20. Marrazzi, A. S., and Hart, E. R., Science, 1955, 121, 365.CrossRefGoogle Scholar
21. McDermott, W. V., and Adams, R. D., J. Clin. Invest., 1954, 33, 1.CrossRefGoogle Scholar
22. McGeer, P. L., McNair, F. E., McGeer, E. G., and Gibson, W. C., J. Nerv. Ment. Dis., 1957, 125, 166.CrossRefGoogle Scholar
23. Osmond, H., and Smythies, J., J. Ment. Sci., 1952, 98, 309.CrossRefGoogle Scholar
24. Patzig, B., and Block, W., Naturwissenschaften, 1953, 40, 13.CrossRefGoogle Scholar
25. Phear, E. A., Ruebner, B., Sherlock, S., and Summerskill, W. H. J., Clin. Sci., 1956, 15, 93.Google Scholar
26. Pletscher, A., Shore, P. A., and Brodie, B. B., J. Pharm. and Exp. Ther., 1956, 116, 84.Google Scholar
27. Quastel, J. H., and Wales, W. T., Lancet, 1940, i, 402.CrossRefGoogle Scholar
28. Richter, D., in Schizophrenia Somatic Aspects (Ed.: Richter, D.), 1957, p. 56.Google Scholar
29. Riegelhaupt, L. M., J. Nerv. Ment. Dis., 1956, 123, 383.CrossRefGoogle Scholar
30. Idem , ibid., 1958, 127, 228.Google Scholar
31. Rinkel, M., and Solomon, H. C., J. Clin. and Exp. Psychopath., 1957, 18, 323.Google Scholar
32. Rodnight, R., and Aves, E. K., J. Ment. Sci., 1958, 104, 1149.CrossRefGoogle Scholar
33. Ross, E. L., Arch. Int. Med., 1913, 12, 112.CrossRefGoogle Scholar
34. Shattock, F. M., J. Ment. Sci., 1950, 96, 32.CrossRefGoogle Scholar
35. Smith, I., Chromatographie Techniques, 1958. London.Google Scholar
36. Smith, S., J. Nerv. Ment. Dis., 1954, 120, 248.CrossRefGoogle Scholar
37. Summerskill, W. H. T., Brit. Med. J., 1958, ii, 1322.CrossRefGoogle Scholar
38. Todrich, A., Dick, M., and Tait, A. C., ibid., 1958, i, 496.Google Scholar
39. Townsend, A. A. D., J. Ment. Sci., 1905, 51, 51.CrossRefGoogle Scholar
40. Udenfriend, S., Titus, E. O., and Paterson, R. E., J. Biol. Chem., 1956, 219, 335.CrossRefGoogle Scholar
41. Williams, W. J., and Elvehjem, C. A., ibid., 1950, 183, 539.Google Scholar
42. Woolley, D. W., and Shaw, E., Science, 1954, 119, 587.Google Scholar
43. Zimmermann, F. H., Gallman, M., and Eaton, M. T., Amer. J. Psychiat., 1948, 105, 225.CrossRefGoogle Scholar
Submit a response

eLetters

No eLetters have been published for this article.