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The Effect of Sodium Evipan on the Cerebro-Spinal Fluid Pressure

Published online by Cambridge University Press:  19 February 2018

E. N. Butler
E. N. Butler*
Affiliation:
Cane Hill Mental Hospital, Coulsdon, Surrey
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Extract

In view of the increasing use of intravenous sodium evipan as an anaesthetic, any contribution to the knowledge of its pharmacology would seem to be of value. It is known from experimental work and from clinical reports that injection of this drug causes a depression of both respiration and blood-pressure, and that jactitations or twitchings are often present during induction. The report of the Anaesthetics Committee of the Medical Research Council (1) states that there is generally a decrease in the rate of respiration, and that there is a transient fall in systolic blood-pressure of 20–30 mm. Hg. Weese (2) observed a decrease in rate and amplitude of respiration, and a fall of blood-pressure of not more than 20 mm. Hg. Jarman (3) found a fall of 20 mm. or more.

Type
Part I.—Original Articles
Information
Journal of Mental Science , Volume 82 , Issue 337 , March 1936 , pp. 131 - 135
Copyright
Copyright © Royal College of Psychiatrists, 1936 

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References

1 Lancet, July 1, 1933, ii, p. 43.Google Scholar
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10 Idem , ibid., 1932, xxvii, p. 1326.Google Scholar
11 Pickering, G. W. and Hess, W., Clinical Science, 1933, i, p. 77.Google Scholar
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