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The Concentration of Adrenaline in Human Plasma and its Relation to Mental Activity

Published online by Cambridge University Press:  08 February 2018

H. Weil-Malherbe
H. Weil-Malherbe*
Affiliation:
Runwell Hospital, Wickford, Essex
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Extract

It is generally accepted that situations of danger, stress or emergency lead to an increased activity of the sympathetic system and to the discharge of adrenaline from the adrenal medulla. Until recently our knowledge was based, essentially, upon two lines of evidence; on the observation of effector organs and mechanisms, such as heart rate, blood pressure, width of skin capillaries, etc., and on the measurement of the adrenaline concentration in the suprarenals or the suprarenal veins, which contain comparatively large quantities. Lately, with the advent of more refined techniques, further methods have become available, which made it possible to estimate adrenaline in tissues other than the suprarenals, in urine and in peripheral blood. The last two methods are obviously of special importance for clinical studies.

In this paper work done in the writer's laboratory will be briefly reviewed. The first part deals with the development of a method for the estimation of adrenaline and noradrenaline in plasma and with experiments that were intended to establish the validity of the method. The concentration of adrenaline and noradrenaline, and the form of their occurrence, in plasma and CSF, will be discussed. In the second part results will be described, which suggest that there is a correlation of the blood-adrenaline level with mental activity.

Type
Original Articles
Information
Journal of Mental Science , Volume 101 , Issue 425 , October 1955 , pp. 733 - 755
Copyright
Copyright © Royal College of Psychiatrists, 1955 

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References

Cannon, W. B., Physiol. Reviews, 1929, 9, 399.CrossRefGoogle Scholar
Code, C. F., Physiol. Reviews, 1952, 32, 47.CrossRefGoogle Scholar
D'Silva, J. L., Biochem. J., 1937, 31, 2171.Google Scholar
Dunér, H., Acta physiol. scand., 1953, 28, suppl. 102. Google Scholar
von Euler, U. S., Ergebn. Physiol., 1950, 46, 261.Google Scholar
Folkow, B., and von Euler, U. S., Circulation Research, 1954, 2, 191.Google Scholar
Gaddum, J. H., and Schild, H., J. Physiol., 1934, 80, 9 P.Google Scholar
Hagen, P., J. Physiol., 1954, 123, 53 P.Google Scholar
Hökfelt, B., Acta physiol. scand., 1951, 25, suppl. 92. Google Scholar
Holzbauer, M., and Vogt, M., Brit. J. Pharmacol., 1954, 9, 249.Google Scholar
Houssay, A., and Rapela, C. F., Arch. exp. Path. Pharmakol., 1953, 219, 156.Google Scholar
Lehmann, G., and Michaelis, H. F., Arbeitsphysiologie, 1942, 12, 264.Google Scholar
Liddell, D. W., and Weil-Malherbe, H., J. Neurol., Neurosurg. and Psychiat., 1953, 16, 7.CrossRefGoogle Scholar
Lund, A., Acta pharmacol. tox., Kbh., 1949, 5, 231.Google Scholar
Idem , ibid, 1950, 6, 137.Google Scholar
Montagu, J. D., J. ment. Sci., 1955, 101, 110.CrossRefGoogle Scholar
Pekkarinen, A., Acta physiol. scand., 1948, 16, suppl. 54.Google Scholar
Rand, M., and Reid, G., Nature, 1951, 168, 385.Google Scholar
Renton, G. H., and Weil-Malherbe, H., 1955. To be published. Google Scholar
Sutherland, E. W., Ann. N.Y. Acad. Sci., 1951, 54, 693.Google Scholar
Idem and Cori, C. F., J. biol. Chem., 1951, 188, 531.Google Scholar
Wada, M., and Kanowoka, K., Tohoku J. exp. Med., 1935, 27, 1.Google Scholar
Weil-Malherbe, H., J. ment. Sci., 1949, 95, 930.Google Scholar
Idem , Proc. First Intern. Symposium Neurochem., 1954a. In the press.Google Scholar
Idem , 1954b. Unpublished observations.Google Scholar
Idem , J. ment. Sci., 1955, 101, 156.Google Scholar
Idem , and Bone, A. D., Biochem. J., 1952a, 51, 311.Google Scholar
Idem , J. ment. Sci., 1952b, 98, 565.CrossRefGoogle Scholar
Idem , Lancet, 1953, 264, 974.Google Scholar
Idem , Biochem. J., 1954a, 58, 132.CrossRefGoogle Scholar
Idem , Nature, 1954b, 174, 557.Google Scholar
Idem , J. Endocrinol., 1954c, 11, 285.CrossRefGoogle Scholar
Idem , ibid, 1954d, 11, 298.Google Scholar
Weil-Malherbe, H., and Liddell, D. W., J. Neurol., Neurosurg. and Psychiat., 1954, 17, 247.CrossRefGoogle Scholar
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