Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-26T04:56:56.299Z Has data issue: false hasContentIssue false

The Clinical Value and Significance of Leucocytosis in Mental Disease

Published online by Cambridge University Press:  19 February 2018

D. J. Jackson*
Affiliation:
Cardiff City Mental Hospital, County Asylum, Chester

Extract

The problem of leucocytosis has been the subject of much discussion in recent years. Amongst the earlier workers on the subject Virchow stands prominent, and he first gave the name of leucocytosis to a temporary increase in the number of leucocytes in the blood, this occurring both in physiological and pathological conditions. During the past twenty years special attention has been paid to this phenomenon, bringing to light some very important information. Amongst later workers Metchnikoff has done more to enlighten us as to the problem than any other worker. To briefly recapitulate his doctrine. The leucocytes protect the organism against harmful germs by catching them up in their pseudopods, by investing them, and thus robbing them of the possibility of exerting their deleterious action externally. The termination of an infective process would therefore depend alone on whether leucocytes possessing this function are present in the blood in sufficient numbers to overcome the invasion of the germs. The doctrine of Metchnikoff has been modified and also extended by other workers, notably Denys, Löwy, and Richter, who have proved that the value of the leucocytes does not depend on their pseudopods, but that their chemical products yield the strongest protection to the organism. The leucocytes are able by means of the bactericidal or antitoxic substances which they give off to paralyse the toxins produced by the bacteria, and in this way render the microbes harmless by depriving them of the weapons of attack, even if they cannot destroy them.

Type
Part I.—Original Articles
Copyright
Copyright © Royal College of Psychiatrists, 1914 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

(1) Graziani, .—“Ricerche sulle modificazioni citologiche del sangue nelle principali psicosi,” Riv. Sper. Freniatria, 1911.Google Scholar
(2) Howard, S. C.“The Systematic Estimation of the Leucocytosis in certain Cases of Insanity, with Special Reference to the Toxæmic Theory,” Journ. Ment Sci., January, 1910.Google Scholar
(3) Jakob, .—“Ueber Leukocytose,” XV Kongress innere f. Medizin, 1897, Zeitschr. f. klin. Medizin, vols, xxx and xxxii.Google Scholar
(4) Loewy, and Richter, .—“Zur Biologie der Leukocyten,” Virchaw's Archiv, 1898, vol. cli.Google Scholar
(5) Psanna-Salaris, .—“Ricerche urologiche ed ematologiche nei psicopatici,” Riv. di pat. nerv. e ment., 1908.Google Scholar
(6) Sandri, .—“La formula emoleucocitaria nella demenza precoce,” Ibid., 1905.Google Scholar
(7) White, E. B.“The Bacteriological Examination of the Urine in some Cases of General Paralysis,” Journ. Ment Sci., October, 1913.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.